What the FDA labels say about taking them together
Digoxin and glycopyrrolate
Glycopyrrolate's FDA label (Cuvposa) of December 19, 2024 names digoxin in its drug interactions section; the digoxin labels PlainMeds reads (3) do not name glycopyrrolate. The glycopyrrolate label: “DRUG INTERACTIONS Digoxin tablets: Use with glycopyrrolate can increase digoxin serum levels.”
Check it at the source: the digoxin FDA label on DailyMed (effective December 5, 2024, Advanz Pharma (US) Corp.); the glycopyrrolate FDA label on DailyMed (effective October 9, 2025, Hikma Pharmaceuticals USA Inc.).
What does the digoxin label say about glycopyrrolate?
Digoxin's label (effective December 5, 2024) and its 2 other brand-application labels do not name glycopyrrolate in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (LANOXIN), Advanz Pharma (US) Corp., effective December 5, 2024 (SPL set d91e3646-4c63-4512-ab22-db39c085c4dc), via openFDA; the full label on DailyMed
What does the glycopyrrolate label say about digoxin?
Cuvposa label (Merz Pharmaceuticals, LLC, December 19, 2024), drug interactionsDRUG INTERACTIONS Digoxin tablets: Use with glycopyrrolate can increase digoxin serum levels.
Source: FDA drug label (Cuvposa, NDA022571), Merz Pharmaceuticals, LLC, effective December 19, 2024 (SPL set d200bd44-9856-4104-a29e-a4cca3db6737), via openFDA
Source: FDA drug label (Glycopyrrolate), Hikma Pharmaceuticals USA Inc., effective October 9, 2025 (SPL set 960d2dd0-008d-4ec1-ba2e-9388b28b23e2), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Digoxin | Glycopyrrolate | |
|---|---|---|
| Labeled for | Heart failure, Atrial fibrillation | n/a |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.133 per tablet 125 mcg tablet | $1.51 per mL 0.2 mg/mL vial |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once