Amiodarone · more major-labeled pairs than Digoxin
SPL labels Digoxin + Amiodarone as minor; Digoxin 105 / Amiodarone 29 in that band.
Mechanism on file: Amiodarone makes it harder for your body to get rid of digoxin, leading to a large increase in digoxin levels. This can cause the drug to build up to toxic levels in your system.
FDA SPL severity: Minor
Digoxin + Amiodarone · SPL mechanism field
Amiodarone makes it harder for your body to get rid of digoxin, leading to a large increase in digoxin levels. This can cause the drug to build up to toxic levels in your system.
Minor band excerpt · Digoxin with Amiodarone
7.2 Pharmacokinetic Drug Interactions Digoxin concentrations increased greater than 50% Digoxin Serum Concentration Increase Digoxin AUC Increase Recommendations Amiodarone 70% NA Measure serum digoxin concentrations before initiating concomitant drugs.
Digoxin · 120 SPL pairs (broader portfolio than Amiodarone)
- Acarbose minor
- Albuterol minor
- Atorvastatin minor
- Azithromycin minor
Amiodarone · 4 major-labeled pairs (vs Digoxin's 2)
- Atenolol minor
- Atorvastatin minor
- Carvedilol minor
- Cholestyramine minor
FDA Drug Labels (SPL) via openFDA. Registry display only. Not medical advice.
Read our methodology - how this data is sourced, computed, and verified.