Dicloxacillin and Tetracycline Interaction
Drug interaction information between Dicloxacillin and Tetracycline.
Dicloxacillin and Tetracycline have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Dicloxacillin and Tetracycline. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Tetracycline stops bacteria from growing, which can prevent dicloxacillin from killing the bacteria effectively.
FDA Label Information
Drug Interactions Tetracycline, a bacteriostatic antibiotic, may antagonize the bactericidal effect of penicillin and concurrent use of these drugs should be avoided.
Dicloxacillin Also Interacts With
- Warfarin minor
- Probenecid minor
Tetracycline Also Interacts With
- Theophylline major
- Doxycycline moderate
- Doxycycline Hyclate moderate
- Minocycline moderate
- Zinc Sulfate minor
Frequently Asked Questions
What SPL severity band is on file for Dicloxacillin + Tetracycline?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Tetracycline has 12 labeled pairs on file vs Dicloxacillin's 3. In the minor band specifically: Dicloxacillin has 3 (also Warfarin, Probenecid); Tetracycline has 8 (also Zinc Sulfate, Atovaquone/Proguanil, Cholestyramine, Colestipol).
What mechanism field is on file for Dicloxacillin and Tetracycline?
Tetracycline stops bacteria from growing, which can prevent dicloxacillin from killing the bacteria effectively.
Tetracycline carries more major-labeled pairs than Dicloxacillin
SPL source-record counts only. This page's band is minor · classes on file: Dicloxacillin (Penicillinase-Resistant Penicillin); Tetracycline (Tetracycline Antibiotic).
Tetracycline has 1 major-labeled pair vs Dicloxacillin's 0. This page itself is in the minor band, not the major band.
0 major · 0 moderate · 3 minor · 3 total
- Other minor peers for Dicloxacillin
- Warfarin
- Probenecid
1 major · 3 moderate · 8 minor · 12 total
- Other minor peers for Tetracycline
- Zinc Sulfate
- Atovaquone/Proguanil
- Cholestyramine
- Colestipol
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.