What the FDA labels say about taking them together
Dicloxacillin and linezolid
Linezolid's FDA label of June 19, 2026 names dicloxacillin in its warnings and precautions section; the dicloxacillin label PlainMeds reads does not name linezolid. The linezolid label: “… mortality was seen in patients treated with linezolid relative to vancomycin/dicloxacillin/oxacillin in an open-label study in seriously ill patients with intravascular catheter-related infections [78/363 (21.5%) vs. …”
Check it at the source: the dicloxacillin FDA label on DailyMed (effective December 27, 2023, Aurobindo Pharma Limited); the linezolid FDA label on DailyMed (effective June 19, 2026, Hospira, Inc.).
What does the dicloxacillin label say about linezolid?
Dicloxacillin's label (effective December 27, 2023) does not name linezolid in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (DICLOXACILLIN SODIUM), Aurobindo Pharma Limited, effective December 27, 2023 (SPL set 9074b5a6-850c-4144-9097-bb21073ee54d), via openFDA; the full label on DailyMed
What does the linezolid label say about dicloxacillin?
Linezolid label, warnings and precautionsImbalance in an Investigational Study in Patients With Catheter-Related Bloodstream Infections, Including Those With Catheter-Site Infections An imbalance in mortality was seen in patients treated with linezolid relative to vancomycin/dicloxacillin/oxacillin in an open-label study in seriously ill patients with intravascular catheter-related infections [78/363 (21.5%) vs. 58/363 (16.0%); odds ratio 1.426, 95% CI 0.970, 2.098].
Zyvox label (Pharmacia & Upjohn Company LLC, July 9, 2026), warnings and precautionsInform patients of the increased risk of serotonin syndrome when ZYVOX is used concomitantly with serotonergic agents. 5.4 Mortality Imbalance in an Investigational Study in Patients with Catheter-Related Bloodstream Infections, Including Those with Catheter-Site Infections An imbalance in mortality was seen in patients treated with linezolid relative to vancomycin/dicloxacillin/oxacillin in an open-label study in seriously ill patients with intravascular catheter-related infections [78/363 (21.5%) vs. 58/363 (16.0%); odds ratio 1.426, 95% CI 0.970, 2.098].
Source: FDA drug label (Zyvox, NDA021131), Pharmacia & Upjohn Company LLC, effective July 9, 2026 (SPL set 3e5e9975-6f36-42e4-ab46-0e75dda83592), via openFDA
Source: FDA drug label (Linezolid), Hospira, Inc., effective June 19, 2026 (SPL set c401f1a8-cc37-461b-bfef-f2e156629bf8), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Dicloxacillin | Linezolid | |
|---|---|---|
| Labeled for | n/a | Bacterial infections |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.590 per capsule 250 mg capsule | $1.44 per tablet 600 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once