What the FDA labels say about taking them together
Dexlansoprazole and voriconazole
Dexlansoprazole's FDA label of February 17, 2025 names voriconazole in its drug interactions section; voriconazole's label does not name dexlansoprazole itself but warns about its class (Proton pump inhibitors (PPIs)). The dexlansoprazole label: “Increased exposure of dexlansoprazole is expected when used concomitantly with strong inhibitors.”
Check it at the source: the dexlansoprazole FDA label on DailyMed (effective February 17, 2025, Takeda Pharmaceuticals America, Inc.); the voriconazole FDA label on DailyMed (effective February 26, 2026, Roerig).
What does the dexlansoprazole label say about voriconazole?
Dexlansoprazole label, drug interactionsCYP2C19 or CYP3A4 Inhibitors Clinical Impact: Increased exposure of dexlansoprazole is expected when used concomitantly with strong inhibitors. Intervention: Voriconazole: See prescribing information.
Source: FDA drug label (Dexilant), Takeda Pharmaceuticals America, Inc., effective February 17, 2025 (SPL set 9819f033-3bbe-442e-8e92-45fec77b237d), via openFDA; the full label on DailyMed
What does the voriconazole label say about dexlansoprazole?
Voriconazole's label does not name dexlansoprazole itself; it warns about its class (Proton pump inhibitors (PPIs)):
Voriconazole label, drug interactionsThe metabolism of other proton pump inhibitors that are CYP2C19 substrates may also be inhibited by voriconazole and may result in increased plasma concentrations of other proton pump inhibitors.
Source: FDA drug label (VFEND), NDA021630 (Pf Prism Cv), as published by Roerig, effective February 26, 2026 (SPL set ce3ef5cf-3087-4d92-9d94-9eb8287228db), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Dexlansoprazole | Voriconazole | |
|---|---|---|
| Labeled for | Acid reflux and ulcers | Fungal infections |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $3.71 per capsule 60 mg capsule | $1.88 per tablet 200 mg tablet |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once