What the FDA labels say about taking them together
Cobicistat and timolol
Cobicistat's FDA label of February 10, 2026 names timolol in its drug interactions section; the timolol labels PlainMeds reads (4) do not name cobicistat. The cobicistat label: “Clinical monitoring is recommended for coadministration with beta-blockers that are metabolized by CYP2D6.”
Check it at the source: the cobicistat FDA label on DailyMed (effective February 10, 2026, Gilead Sciences, Inc.); the timolol FDA label on DailyMed (effective June 27, 2025, Thea Pharma Inc.).
What does the cobicistat label say about timolol?
Cobicistat label, drug interactionsConcomitant Drug Class/Drug Name: Beta-Blockers: e.g., metoprolol carvedilol timolol; Potential Effect ↑ = Increase, ↓ = Decrease, ↔ = No change: ↑ beta-blockers; Clinical Comment: Clinical monitoring is recommended for coadministration with beta-blockers that are metabolized by CYP2D6.
Source: FDA drug label (Tybost), Gilead Sciences, Inc., effective February 10, 2026 (SPL set 3784c35c-e87f-410c-900b-8fd6313c6010), via openFDA; the full label on DailyMed
What does the timolol label say about cobicistat?
Timolol's label (effective June 27, 2025) and its 3 other brand-application labels do not name cobicistat in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (BETIMOL), Thea Pharma Inc., effective June 27, 2025 (SPL set 3ae775f4-340c-4bf4-aa49-8a31daba0f8b), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Cobicistat | Timolol | |
|---|---|---|
| Labeled for | HIV | Glaucoma, High blood pressure, Migraine |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | n/a | $0.774 per mL 0.5% eye drops |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once