What the FDA labels say about taking them together
Cobicistat and thioridazine
Cobicistat's FDA label of February 10, 2026 names thioridazine in its drug interactions section; the thioridazine label PlainMeds reads does not name cobicistat. The cobicistat label: “A decrease in the dose of antipsychotics that are metabolized by CYP3A or CYP2D6 may be needed upon coadministration.”
Check it at the source: the cobicistat FDA label on DailyMed (effective February 10, 2026, Gilead Sciences, Inc.); the thioridazine FDA label on DailyMed (effective November 11, 2025, Mylan Institutional Inc.).
What does the cobicistat label say about thioridazine?
Cobicistat label, drug interactionsConcomitant Drug Class/Drug Name: Other antipsychotics: e.g., perphenazine risperidone thioridazine; Potential Effect ↑ = Increase, ↓ = Decrease, ↔ = No change: ↑ antipsychotic; Clinical Comment: A decrease in the dose of antipsychotics that are metabolized by CYP3A or CYP2D6 may be needed upon coadministration.
Source: FDA drug label (Tybost), Gilead Sciences, Inc., effective February 10, 2026 (SPL set 3784c35c-e87f-410c-900b-8fd6313c6010), via openFDA; the full label on DailyMed
What does the thioridazine label say about cobicistat?
Thioridazine's label (effective November 11, 2025) does not name cobicistat in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Thioridazine Hydrochloride), Mylan Institutional Inc., effective November 11, 2025 (SPL set 52fea941-0b47-41c1-b00d-f88150e8ab93), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Cobicistat | Thioridazine | |
|---|---|---|
| Labeled for | HIV | n/a |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | n/a | $0.571 per tablet 25 mg tablet |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once