What the FDA labels say about taking them together
Cobicistat and digoxin
Cobicistat's FDA label of February 10, 2026 names digoxin in its drug interactions section; the digoxin labels PlainMeds reads (3) do not name cobicistat. The cobicistat label: “When coadministering with digoxin, titrate the digoxin dose and monitor digoxin concentrations.”
Check it at the source: the cobicistat FDA label on DailyMed (effective February 10, 2026, Gilead Sciences, Inc.); the digoxin FDA label on DailyMed (effective December 5, 2024, Advanz Pharma (US) Corp.).
What does the cobicistat label say about digoxin?
Cobicistat label, drug interactionsConcomitant Drug Class/Drug Name: digoxin; Potential Effect ↑ = Increase, ↓ = Decrease, ↔ = No change: ↑ digoxin; Clinical Comment: When coadministering with digoxin, titrate the digoxin dose and monitor digoxin concentrations.
Source: FDA drug label (Tybost), Gilead Sciences, Inc., effective February 10, 2026 (SPL set 3784c35c-e87f-410c-900b-8fd6313c6010), via openFDA; the full label on DailyMed
What does the digoxin label say about cobicistat?
Digoxin's label (effective December 5, 2024) and its 2 other brand-application labels do not name cobicistat in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (LANOXIN), Advanz Pharma (US) Corp., effective December 5, 2024 (SPL set d91e3646-4c63-4512-ab22-db39c085c4dc), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Cobicistat | Digoxin | |
|---|---|---|
| Labeled for | HIV | Heart failure, Atrial fibrillation |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | n/a | $0.133 per tablet 125 mcg tablet |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once