What the FDA labels say about taking them together
Clonazepam and cobicistat
Cobicistat's FDA label of February 10, 2026 names clonazepam in its drug interactions section; the clonazepam label PlainMeds reads does not name cobicistat. The cobicistat label: “Clinical monitoring of anticonvulsants is recommended.”
Check it at the source: the clonazepam FDA label on DailyMed (effective December 1, 2025, H2-Pharma, LLC); the cobicistat FDA label on DailyMed (effective February 10, 2026, Gilead Sciences, Inc.).
What does the clonazepam label say about cobicistat?
Clonazepam's label (effective December 1, 2025) does not name cobicistat in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Klonopin), NDA017533 (Cheplapharm), as published by H2-Pharma, LLC, effective December 1, 2025 (SPL set cfa0d79a-843c-4b88-95a1-e9511d649ca1), via openFDA; the full label on DailyMed
What does the cobicistat label say about clonazepam?
Cobicistat label, drug interactionsConcomitant Drug Class/Drug Name: Anticonvulsants that are metabolized by CYP3A e.g., clonazepam; Potential Effect ↑ = Increase, ↓ = Decrease, ↔ = No change: ↑ clonazepam; Clinical Comment: Clinical monitoring of anticonvulsants is recommended.
Source: FDA drug label (Tybost), Gilead Sciences, Inc., effective February 10, 2026 (SPL set 3784c35c-e87f-410c-900b-8fd6313c6010), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Clonazepam | Cobicistat | |
|---|---|---|
| Labeled for | Seizures and epilepsy, Anxiety | HIV |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.0244 per tablet 1 mg tablet | n/a |
| Shortage now | In shortage | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once