What the FDA labels say about taking them together
Ciprofloxacin and olanzapine
Ciprofloxacin's FDA label of March 2, 2026 names olanzapine in its warnings and precautions section; the olanzapine labels PlainMeds reads (3) do not name ciprofloxacin. The ciprofloxacin label: “Co-administration of CIPRO and other drugs primarily metabolized by CYP1A2, results in increased plasma concentrations of the co-administered drug and could lead to clinically significant pharmacodynamic adverse …”
Check it at the source: the ciprofloxacin FDA label on DailyMed (effective March 2, 2026, Bayer HealthCare Pharmaceuticals Inc.); the olanzapine FDA label on DailyMed (effective March 5, 2026, Macleods Pharmaceuticals Limited).
What does the ciprofloxacin label say about olanzapine?
Ciprofloxacin label, warnings and precautionsCo-administration of CIPRO and other drugs primarily metabolized by CYP1A2 (for example, theophylline, methylxanthines, caffeine, tizanidine, ropinirole, clozapine, olanzapine and zolpidem), results in increased plasma concentrations of the co-administered drug and could lead to clinically significant pharmacodynamic adverse reactions of the co-administered drug [see Drug Interactions ( 7 ) and Clinical Pharmacology ( 12.3 )].
Source: FDA drug label (Cipro), Bayer HealthCare Pharmaceuticals Inc., effective March 2, 2026 (SPL set 888dc7f9-ad9c-4c00-8d50-8ddfd9bd27c0), via openFDA; the full label on DailyMed
What does the olanzapine label say about ciprofloxacin?
Olanzapine's label (effective March 5, 2026) and its 2 other brand-application labels do not name ciprofloxacin in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Olanzapine), Macleods Pharmaceuticals Limited, effective March 5, 2026 (SPL set 8e095987-bdea-42f2-9550-c7155cf07d30), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Ciprofloxacin | Olanzapine | |
|---|---|---|
| Labeled for | Diarrhea, Urinary tract infections, Bacterial infections | Schizophrenia, Bipolar disorder, Depression |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.123 per tablet 500 mg tablet | $0.147 per tablet 20 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once