What the FDA labels say about taking them together
Ciprofloxacin and glimepiride
Ciprofloxacin's FDA label of March 2, 2026 names glimepiride in its drug interactions section; glimepiride's label does not name ciprofloxacin itself but warns about its class (Fluoroquinolones). The ciprofloxacin label: “Oral antidiabetic drugs; Use with caution Glucose-lowering effect potentiated; Hypoglycemia sometimes severe has been reported when CIPRO and oral antidiabetic agents, mainly sulfonylureas, were co-administered …”
Check it at the source: the ciprofloxacin FDA label on DailyMed (effective March 2, 2026, Bayer HealthCare Pharmaceuticals Inc.); the glimepiride FDA label on DailyMed (effective May 12, 2025, Micro Labs Limited).
What does the ciprofloxacin label say about glimepiride?
Ciprofloxacin label, drug interactionsOral antidiabetic drugs; Use with caution Glucose-lowering effect potentiated; Hypoglycemia sometimes severe has been reported when CIPRO and oral antidiabetic agents, mainly sulfonylureas (for example, glyburide, glimepiride), were co-administered, presumably by intensifying the action of the oral antidiabetic agent. Fatalities have been reported. Monitor blood glucose when CIPRO is co-administered with oral antidiabetic drugs [see Adverse Reactions ()].
Source: FDA drug label (Cipro), Bayer HealthCare Pharmaceuticals Inc., effective March 2, 2026 (SPL set 888dc7f9-ad9c-4c00-8d50-8ddfd9bd27c0), via openFDA; the full label on DailyMed
What does the glimepiride label say about ciprofloxacin?
Glimepiride's label does not name ciprofloxacin itself; it warns about its class (Fluoroquinolones):
Glimepiride label, drug interactionsThe following are examples of medications that may increase the glucose-lowering effect of sulfonylureas including glimepiride, increasing the susceptibility to and/or intensity of hypoglycemia: oral anti-diabetic medications, pramlintide acetate, insulin, angiotensin converting enzyme (ACE) inhibitors, H 2 receptor antagonists, fibrates, propoxyphene, pentoxifylline, somatostatin analogs, anabolic steroids and androgens, cyclophosphamide, phenyramidol, guanethidine, fluconazole, sulfinpyrazone, tetracyclines …
Source: FDA drug label (Glimepiride), Micro Labs Limited, effective May 12, 2025 (SPL set 60e9397e-83b9-489e-9683-6f87e458bbaa), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Ciprofloxacin | Glimepiride | |
|---|---|---|
| Labeled for | Diarrhea, Urinary tract infections, Bacterial infections | Type 2 diabetes |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.123 per tablet 500 mg tablet | $0.0507 per tablet 4 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once