Rifampin · more major-labeled pairs than Caspofungin
SPL labels Caspofungin + Rifampin as minor; Caspofungin 6 / Rifampin 103 in that band.
Mechanism on file: Rifampin increases the activity of enzymes that break down other drugs, which reduces the amount of caspofungin available to fight infection.
FDA SPL severity: Minor
Caspofungin + Rifampin · SPL mechanism field
Rifampin increases the activity of enzymes that break down other drugs, which reduces the amount of caspofungin available to fight infection.
Minor band excerpt · Caspofungin with Rifampin
Telaprevir Decrease AUC by 92% Systemic Hormonal Contraceptives Prevention or Management: Advise patients to change to non-hormonal methods of birth control during rifampin therapy Estrogens Decrease exposure Progestins Anticonvulsants Phenytoin Administered with rifampin 450 mg daily Decrease exposure Antiarrhythmics Disopyramide Decrease exposure Mexiletine Decrease exposure Quinidine Decrease exposure Propafenone Decrease AUC by 50%–67% Tocainide Decrease exposure Antiestrogens Tamoxifen Decrease AUC by 86% Toremifene Decrease steady state concentrations of toremifene in serum...
Caspofungin · 6 minor + 6 total pairs
- Carbamazepine minor
- Cyclosporine minor
- Dexamethasone minor
- Phenytoin minor
Rifampin · 8 major-labeled pairs (vs Caspofungin's 0)
- Abiraterone minor
- Acetaminophen/Oxycodone minor
- Anidulafungin minor
- Apremilast minor
FDA Drug Labels (SPL) via openFDA. Registry display only. Not medical advice.
Read our methodology - how this data is sourced, computed, and verified.