What the FDA labels say about taking them together
Caspofungin and cyclosporine
Caspofungin's FDA label of October 11, 2024 names cyclosporine in its drug interactions section; the cyclosporine labels PlainMeds reads (4) do not name caspofungin. The caspofungin label: “DRUG INTERACTIONS Cyclosporine: In two adult clinical studies, cyclosporine increased the AUC of CANCIDAS.”
Check it at the source: the caspofungin FDA label on DailyMed (effective October 11, 2024, Merck Sharp & Dohme LLC); the cyclosporine FDA label on DailyMed (effective August 10, 2026, Novartis Pharmaceuticals Corporation).
What does the caspofungin label say about cyclosporine?
Caspofungin label, drug interactionsDRUG INTERACTIONS Cyclosporine: In two adult clinical studies, cyclosporine (one 4 mg/kg dose or two 3 mg/kg doses) increased the AUC of CANCIDAS.
Caspofungin label, warnings and precautionsMonitor patients who develop abnormal liver enzymes for evidence of worsening hepatic function, and evaluate risk/benefit of continuing CANCIDAS. ( 5.2 ) Elevated Liver Enzymes During Concomitant Use with Cyclosporine:
Caspofungin Acetate label (Fresenius Kabi USA, LLC, January 8, 2026), warnings and precautionsElevated Liver Enzymes during Concomitant use with Cyclosporine: Limit use to patients for whom potential benefit outweighs potential risk.
Source: FDA drug label (Caspofungin Acetate, NDA206110), Fresenius Kabi USA, LLC, effective January 8, 2026 (SPL set e76d8d83-3691-451c-a32c-d91448c54d16), via openFDA
Source: FDA drug label (CANCIDAS), Merck Sharp & Dohme LLC, effective October 11, 2024 (SPL set 3bad23a6-09a6-4194-9182-093ed61bc71c), via openFDA; the full label on DailyMed
What does the cyclosporine label say about caspofungin?
Cyclosporine's label (effective August 10, 2026) and its 3 other brand-application labels do not name caspofungin in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Neoral), Novartis Pharmaceuticals Corporation, effective August 10, 2026 (SPL set 94461af3-11f1-4670-95d4-2965b9538ae3), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Caspofungin | Cyclosporine | |
|---|---|---|
| Labeled for | Fungal infections | Organ transplant rejection, Rheumatoid arthritis |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | n/a | $1.04 per unit 0.05% eye emulsion |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once