Rifampin · more major-labeled pairs than Acetaminophen/Oxycodone
SPL labels Rifampin + Acetaminophen/Oxycodone as minor; Rifampin 103 / Acetaminophen/Oxycodone 21 in that band.
Mechanism on file: Rifampin speeds up how fast your body breaks down oxycodone, which makes the pain medicine less effective. This can also cause withdrawal symptoms if you have been taking the pain medicine for a long time.
FDA SPL severity: Minor
Rifampin + Acetaminophen/Oxycodone · SPL mechanism field
Rifampin speeds up how fast your body breaks down oxycodone, which makes the pain medicine less effective. This can also cause withdrawal symptoms if you have been taking the pain medicine for a long time.
Minor band excerpt · Rifampin with Acetaminophen/Oxycodone
Inducers of CYP3A4 The concomitant use of PERCOCET and CYP3A4 inducers, such as rifampin, carbamazepine, and phenytoin, can decrease the plasma concentration of oxycodone [see CLINICAL PHARMACOLOGY ] , resulting in decreased efficacy or onset of a withdrawal syndrome in patients who have developed physical dependence to PERCOCET [see WARNINGS ] .
Rifampin · 8 major-labeled pairs (vs Acetaminophen/Oxycodone's 0)
- Abiraterone minor
- Anidulafungin minor
- Apremilast minor
- Aripiprazole minor
Acetaminophen/Oxycodone · 21 minor + 23 total pairs
- Acetaminophen minor
- Butorphanol minor
- Carbamazepine minor
- Cyclobenzaprine minor
FDA Drug Labels (SPL) via openFDA. Registry display only. Not medical advice.
Read our methodology - how this data is sourced, computed, and verified.