Rifampin · more major-labeled pairs than Apremilast
SPL labels Rifampin + Apremilast as minor; Rifampin 103 / Apremilast 1 in that band.
Mechanism on file: Rifampin causes your body to break down apremilast much faster than normal, which can make it stop working.
FDA SPL severity: Minor
Rifampin + Apremilast · SPL mechanism field
Rifampin causes your body to break down apremilast much faster than normal, which can make it stop working.
Minor band excerpt · Rifampin with Apremilast
7 DRUG INTERACTIONS 7.1 Strong CYP450 Inducers Co-administration with strong CYP450 inducers (such as rifampin) decreases apremilast exposure and may result in loss of efficacy of OTEZLA/OTEZLA XR [see Warnings and Precautions (5.5) and Clinical Pharmacology (12.3) ] .
Rifampin · 8 major-labeled pairs (vs Apremilast's 0)
- Abiraterone minor
- Acetaminophen/Oxycodone minor
- Anidulafungin minor
- Aripiprazole minor
FDA Drug Labels (SPL) via openFDA. Registry display only. Not medical advice.
Read our methodology - how this data is sourced, computed, and verified.