Warfarin · more major-labeled pairs than Entacapone
SPL labels Entacapone + Warfarin as minor; Entacapone 1 / Warfarin 133 in that band.
Mechanism on file: Entacapone can increase the levels of warfarin in your system, which may cause your blood to become too thin.
FDA SPL severity: Minor
Entacapone + Warfarin · SPL mechanism field
Entacapone can increase the levels of warfarin in your system, which may cause your blood to become too thin.
Minor band excerpt · Entacapone with Warfarin
In an interaction study in healthy volunteers, entacapone did not significantly change the plasma levels of S-warfarin while the AUC for R-warfarin increased on average by 18% [Cl90 11% to 26%], and the INR values increased on average by 13% [Cl90 6% to 19%]. Nevertheless, cases of significantly increased INR in patients concomitantly using warfarin have been reported during the postapproval use of entacapone. Therefore, monitoring of INR is recommended when entacapone treatment is initiated or when the dose is increased for patients receiving warfarin.
Entacapone · 1 minor + 3 total pairs
- Carbidopa/Levodopa moderate
- Tranylcypromine moderate
Warfarin · 2 major-labeled pairs (vs Entacapone's 0)
- Acyclovir minor
- Adalimumab minor
- Allopurinol minor
- Alprazolam minor
FDA Drug Labels (SPL) via openFDA. Registry display only. Not medical advice.
Read our methodology - how this data is sourced, computed, and verified.