Tranylcypromine · more major-labeled pairs than Entacapone
SPL labels Entacapone + Tranylcypromine as moderate; Entacapone 2 / Tranylcypromine 23 in that band.
Mechanism on file: Using these medications together can cause a sudden, dangerous increase in blood pressure or a serious brain chemical imbalance. Both drugs affect how the body breaks down certain chemicals, leading to a risky buildup.
FDA SPL severity: Moderate
Entacapone + Tranylcypromine · SPL mechanism field
Using these medications together can cause a sudden, dangerous increase in blood pressure or a serious brain chemical imbalance. Both drugs affect how the body breaks down certain chemicals, leading to a risky buildup.
Moderate band excerpt · Entacapone with Tranylcypromine
Product Clinical Comment on Concomitant Use [See Contraindications (4.1)] ; Predominant Effect/Risk [Hypertensive Reaction (HR) [See Warnings and Precautions (5.3)] ; or Serotonin Syndrome (SS) [See Warnings and Precautions (5.7)] ] Altretamine Use with caution If not otherwise specified in this table, consider avoiding concomitant use (see also information on medication-free intervals , use agent at the lowest appropriate dose, monitor for effects of the interaction, advise the patient to report potential effects, and be prepared to discontinue the agent and treat effects of the...
Entacapone · 2 moderate + 3 total pairs
- Carbidopa/Levodopa moderate
- Warfarin minor
Tranylcypromine · 7 major-labeled pairs (vs Entacapone's 0)
- Buspirone moderate
- Carbamazepine moderate
- Chlorpromazine moderate
- Cyclobenzaprine moderate
FDA Drug Labels (SPL) via openFDA. Registry display only. Not medical advice.
Read our methodology - how this data is sourced, computed, and verified.