What the FDA labels say about taking them together
Bupropion and propranolol
Propranolol's FDA label (Inderal Xl) of August 27, 2026 names bupropion in its drug interactions section; bupropion's label does not name propranolol itself but warns about its class (Beta blockers). The propranolol label: “Impact of Other Drugs on Propranolol CYP2D6, CYP1A2 and CYP2C19 Inhibitors: CYP2D6 inhibitors, CYP1A2 inhibitors and CYP2C19 inhibitors increase exposure to propranolol when co-administered with INDERAL XL.”
Check it at the source: the bupropion FDA label on DailyMed (effective June 21, 2024); the propranolol FDA label on DailyMed (effective January 15, 2026, Mylan Pharmaceuticals Inc.).
What does the bupropion label say about propranolol?
Bupropion's label does not name propranolol itself; it warns about its class (Beta blockers):
Bupropion label, drug interactionsBupropion inhibits CYP2D6 and can increase concentrations of: antidepressants (e.g., venlafaxine, nortriptyline, imipramine, desipramine, paroxetine, fluoxetine, sertraline), antipsychotics (e.g., haloperidol, risperidone, thioridazine), beta-blockers (e.g., metoprolol), and Type 1C antiarrhythmics (e.g., propafenone, flecainide).
Bupropion label, drug interactionsSuch drugs include certain antidepressants (e.g., venlafaxine, nortriptyline, imipramine, desipramine, paroxetine, fluoxetine, and sertraline), antipsychotics (e.g., haloperidol, risperidone, thioridazine), beta-blockers (e.g., metoprolol), and Type 1C antiarrhythmics (e.g., propafenone and flecainide).
Source: FDA drug label (BUPROPION HYDROCHLORIDE), Epic Pharma LLC, effective June 21, 2024 (SPL set 9fb44e96-6160-4a4a-90cb-91764c0dcd89), via openFDA; the full label on DailyMed
What does the propranolol label say about bupropion?
Inderal Xl label (ANI Pharmaceuticals, Inc., August 27, 2026), drug interactionsImpact of Other Drugs on Propranolol CYP2D6, CYP1A2 and CYP2C19 Inhibitors: CYP2D6 inhibitors (e.g. bupropion, fluoxetine, paroxetine, quinidine), CYP1A2 inhibitors (e.g., ciprofloxacin, enoxamine, fluvoxamine) and CYP2C19 inhibitors (e.g., fluconazole, fluvoxamine, ticlopidine) increase exposure to propranolol when co-administered with INDERAL XL.
Source: FDA drug label (Inderal Xl, NDA021438), ANI Pharmaceuticals, Inc., effective August 27, 2026 (SPL set ac196ff5-9215-402b-bc57-69aa87f8bade), via openFDA
Source: FDA drug label (Propranolol Hydrochloride), Mylan Pharmaceuticals Inc., effective January 15, 2026 (SPL set b94dcec7-7633-4a33-9cea-48161adeaf93), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Bupropion | Propranolol | |
|---|---|---|
| Labeled for | Depression, Quitting smoking | High blood pressure, Angina, Atrial fibrillation, Migraine |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.0785 per tablet 150 mg tablet | $0.0493 per tablet 20 mg tablet |
| Shortage now | No current entry | In shortage |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once