What the FDA labels say about taking them together
Bupropion and leuprolide
Leuprolide's FDA label (Lupron Depot-Ped) of November 14, 2025 names bupropion in its warnings and precautions section; the bupropion labels PlainMeds reads (4) do not name leuprolide.
Check it at the source: the bupropion FDA label on DailyMed (effective June 21, 2024); the leuprolide FDA label on DailyMed (effective May 28, 2026, Amneal Pharmaceuticals LLC).
What does the bupropion label say about leuprolide?
Bupropion's label (effective June 21, 2024) and its 3 other brand-application labels do not name leuprolide in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (BUPROPION HYDROCHLORIDE), Epic Pharma LLC, effective June 21, 2024 (SPL set 9fb44e96-6160-4a4a-90cb-91764c0dcd89), via openFDA; the full label on DailyMed
What does the leuprolide label say about bupropion?
Lupron Depot-Ped label (AbbVie Inc., November 14, 2025), warnings and precautionsThese included patients with a history of seizures, epilepsy, cerebrovascular disorders, central nervous system anomalies or tumors, and patients on concomitant medications that have been associated with convulsions such as bupropion and SSRIs.
Source: FDA drug label (Lupron Depot-Ped, NDA020263), AbbVie Inc., effective November 14, 2025 (SPL set e99f47d2-da10-3127-ecb3-e5d942ae6e81), via openFDA
Source: FDA drug label (Lupron Depot, NDA020517), AbbVie Inc., effective March 15, 2026 (SPL set cbc8f94e-7330-4465-05ad-16d64493a5dd), via openFDA
Source: FDA drug label (leuprolide acetate), Amneal Pharmaceuticals LLC, effective May 28, 2026 (SPL set 4838c674-044e-46b2-81e7-c691b99d8fa5), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Bupropion | Leuprolide | |
|---|---|---|
| Labeled for | Depression, Quitting smoking | Prostate cancer, Anemia |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.0785 per tablet 150 mg tablet | $197.61 per unit 2wk 14 mg/2.8 mL kt |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once