What the FDA labels say about taking them together
Bupropion and digoxin
Bupropion's FDA label of June 21, 2024 names digoxin in its drug interactions section; the digoxin labels PlainMeds reads (3) do not name bupropion. The bupropion label: “Digoxin Coadministration of bupropion hydrochloride extended-release tablets (SR) with digoxin may decrease plasma digoxin levels.”
Check it at the source: the bupropion FDA label on DailyMed (effective June 21, 2024); the digoxin FDA label on DailyMed (effective December 5, 2024, Advanz Pharma (US) Corp.).
What does the bupropion label say about digoxin?
Bupropion label, drug interactionsDigoxin Coadministration of bupropion hydrochloride extended-release tablets (SR) with digoxin may decrease plasma digoxin levels.
Source: FDA drug label (BUPROPION HYDROCHLORIDE), Epic Pharma LLC, effective June 21, 2024 (SPL set 9fb44e96-6160-4a4a-90cb-91764c0dcd89), via openFDA; the full label on DailyMed
What does the digoxin label say about bupropion?
Digoxin's label (effective December 5, 2024) and its 2 other brand-application labels do not name bupropion in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (LANOXIN), Advanz Pharma (US) Corp., effective December 5, 2024 (SPL set d91e3646-4c63-4512-ab22-db39c085c4dc), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Bupropion | Digoxin | |
|---|---|---|
| Labeled for | Depression, Quitting smoking | Heart failure, Atrial fibrillation |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.0785 per tablet 150 mg tablet | $0.133 per tablet 125 mcg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once