What the FDA labels say about taking them together
Bumetanide and furosemide
Bumetanide's FDA label of September 8, 2025 names furosemide in its warnings section; the furosemide labels PlainMeds reads (4) do not name bumetanide. The bumetanide label: “In these test animals bumetanide was 5 to 6 times more potent than furosemide and, since the diuretic potency of bumetanide is about 40 to 60 times furosemide, it is anticipated that blood levels necessary to produce …”
Check it at the source: the bumetanide FDA label on DailyMed (effective September 8, 2025, Validus Pharmaceuticals LLC); the furosemide FDA label on DailyMed (effective September 30, 2025, Validus Pharmaceuticals LLC).
What does the bumetanide label say about furosemide?
Bumetanide label, warningsIn these test animals bumetanide was 5 to 6 times more potent than furosemide and, since the diuretic potency of bumetanide is about 40 to 60 times furosemide, it is anticipated that blood levels necessary to produce ototoxicity will rarely be achieved.
Source: FDA drug label (Bumex), Validus Pharmaceuticals LLC, effective September 8, 2025 (SPL set 32dfbea3-eb2b-4070-8605-57ce3e6d5a2f), via openFDA; the full label on DailyMed
What does the furosemide label say about bumetanide?
Furosemide's label (effective September 30, 2025) and its 3 other brand-application labels do not name bumetanide in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Lasix), Validus Pharmaceuticals LLC, effective September 30, 2025 (SPL set 2c9b4d8f-0770-482d-a9e6-9c616a440b1a), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Bumetanide | Furosemide | |
|---|---|---|
| Labeled for | Heart failure | Heart failure, High blood pressure, Edema (fluid retention) |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.108 per tablet 1 mg tablet | $0.490 per mL 20 mg/2 mL vial |
| Shortage now | Resolved | In shortage |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once