What the FDA labels say about taking them together
Bumetanide and ethacrynic acid
Bumetanide's FDA label (Enbumyst) of August 27, 2026 names ethacrynic acid in its warnings and precautions section; the ethacrynic acid label PlainMeds reads does not name bumetanide.
Check it at the source: the bumetanide FDA label on DailyMed (effective September 8, 2025, Validus Pharmaceuticals LLC); the ethacrynic acid FDA label on DailyMed (effective August 31, 2020, Bausch Health US, LLC).
What does the bumetanide label say about ethacrynic acid?
Enbumyst label (Corstasis USA LLC, August 27, 2026), warnings and precautionsReports indicate that ototoxicity is associated with rapid injection, severe renal impairment, the use of higher than recommended doses, hypoproteinemia or concomitant therapy with aminoglycoside antibiotics, ethacrynic acid, or other ototoxic drugs.
Source: FDA drug label (Enbumyst, NDA219500), Corstasis USA LLC, effective August 27, 2026 (SPL set d6f752c5-d2bd-4f77-9611-ca2110066d1f), via openFDA
Source: FDA drug label (Bumex), Validus Pharmaceuticals LLC, effective September 8, 2025 (SPL set 32dfbea3-eb2b-4070-8605-57ce3e6d5a2f), via openFDA; the full label on DailyMed
What does the ethacrynic acid label say about bumetanide?
Ethacrynic acid's label (effective August 31, 2020) does not name bumetanide in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (EDECRIN), Bausch Health US, LLC, effective August 31, 2020 (SPL set 1efe378e-fee1-4ae9-8ea5-0fe2265fe2d8), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Bumetanide | Ethacrynic acid | |
|---|---|---|
| Labeled for | Heart failure | Edema (fluid retention), Heart failure |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.108 per tablet 1 mg tablet | $0.807 per tablet 25 mg tablet |
| Shortage now | Resolved | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once