What the FDA labels say about taking them together
Amiodarone and ropivacaine
Ropivacaine's FDA label of August 6, 2024 names amiodarone in its drug interactions section; the amiodarone labels PlainMeds reads (2) do not name ropivacaine. The ropivacaine label: “… are additive. Patients treated with class III antiarrhythmic drugs (e.g., amiodarone) should be under close surveillance and ECG monitoring considered, since cardiac effects may be additive.”
Check it at the source: the amiodarone FDA label on DailyMed (effective December 9, 2025, Chartwell RX, LLC); the ropivacaine FDA label on DailyMed (effective August 6, 2024, Fresenius Kabi USA, LLC).
What does the amiodarone label say about ropivacaine?
Amiodarone's label (effective December 9, 2025) and its 1 other brand-application label do not name ropivacaine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Amiodarone Hydrochloride), Chartwell RX, LLC, effective December 9, 2025 (SPL set 5520f11d-968d-4f4f-bf57-d14369c0d746), via openFDA; the full label on DailyMed
What does the ropivacaine label say about amiodarone?
Ropivacaine label, drug interactionsSpecific trials studying the interaction between ropivacaine and class III antiarrhythmic drugs (e.g., amiodarone) have not been performed, but caution is advised [see Warnings and Precautions ( 5.13 )].
Ropivacaine label, warnings and precautionsRisk of Additive Effects NAROPIN should be used with caution in patients receiving other local anesthetics or agents structurally related to amide- type local anesthetics, since the toxic effects of these drugs are additive. [See Drug Interactions 7.0] Patients treated with class III antiarrhythmic drugs (e.g., amiodarone) should be under close surveillance and ECG monitoring considered, since cardiac effects may be additive. [See Drug Interactions 7.0]
Source: FDA drug label (Naropin), Fresenius Kabi USA, LLC, effective August 6, 2024 (SPL set 23d2d448-a744-4877-9f2d-7e57c198da89), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Amiodarone | Ropivacaine | |
|---|---|---|
| Labeled for | n/a | Pain |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.122 per tablet 200 mg tablet | n/a |
| Shortage now | No current entry | In shortage |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once