What the FDA labels say about taking them together
Amiodarone and phenytoin
Amiodarone's FDA label of December 9, 2025 names phenytoin in its drug interactions section, and phenytoin's label names amiodarone too. The amiodarone label: “Increased steady state levels of phenytoin. Monitor phenytoin levels.”
Check it at the source: the amiodarone FDA label on DailyMed (effective December 9, 2025, Chartwell RX, LLC); the phenytoin FDA label on DailyMed (effective October 15, 2024, Mylan Pharmaceuticals Inc.).
What does the amiodarone label say about phenytoin?
Amiodarone label, drug interactionsConcomitant Drug/Class/Name: Phenytoin; Examples: Increased steady-state levels of phenytoin. Monitor phenytoin levels.
Source: FDA drug label (Nexterone, NDA022325), Baxter Healthcare Corporation, effective April 16, 2024 (SPL set e9108958-b8d7-4fba-87c3-9a32990de551), via openFDA
Source: FDA drug label (Amiodarone Hydrochloride), Chartwell RX, LLC, effective December 9, 2025 (SPL set 5520f11d-968d-4f4f-bf57-d14369c0d746), via openFDA; the full label on DailyMed
What does the phenytoin label say about amiodarone?
Phenytoin label, drug interactionsInteracting Agent: Other; Examples: Acute alcohol intake, amiodarone, chloramphenicol, chlordiazepoxide, disulfiram, estrogen, fluvastatin, isoniazid, methylphenidate, phenothiazines, salicylates, ticlopidine, tolbutamide, trazodone, warfarin
Source: FDA drug label (Phenytek), Mylan Pharmaceuticals Inc., effective October 15, 2024 (SPL set 0f94c791-8b07-4b41-927e-c9f28bec5f60), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Amiodarone | Phenytoin | |
|---|---|---|
| Labeled for | n/a | Seizures and epilepsy |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.122 per tablet 200 mg tablet | $0.145 per capsule 100 mg capsule |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once