What the FDA labels say about taking them together
Amiodarone and levofloxacin
Levofloxacin's FDA label of July 10, 2024 names amiodarone in its warnings and precautions section; amiodarone's label does not name levofloxacin itself but warns about its class (Fluoroquinolones). The levofloxacin label: “… and patients receiving Class IA (quinidine, procainamide), or Class III (amiodarone, sotalol) antiarrhythmic agents.”
Check it at the source: the amiodarone FDA label on DailyMed (effective December 9, 2025, Chartwell RX, LLC); the levofloxacin FDA label on DailyMed (effective July 10, 2024, Lupin Pharmaceuticals, Inc.).
What does the amiodarone label say about levofloxacin?
Amiodarone's label does not name levofloxacin itself; it warns about its class (Fluoroquinolones):
Amiodarone label, drug interactionsAmiodarone Drug Interactions Concomitant Drug Class/Name Examples Clinical Comment Pharmacodynamic Interactions QT Prolonging Drugs class I and III antiarrhythmics, lithium, certain phenothiazines, tricyclic antidepressants, certain fluoroquinolone and macrolide antibiotics, azole antifungals, halogenated inhalation anesthetic agents Increased risk of Torsade de Pointes.
Amiodarone label, drug interactionsPharmacokinetic Interactions CYP450 Inhibitors grapefruit juice, certain fluoroquinolone and macrolide antibiotics, azole antifungals, cimetidine, certain protease inhibitors Increased exposure of amiodarone.
Source: FDA drug label (Amiodarone Hydrochloride), Chartwell RX, LLC, effective December 9, 2025 (SPL set 5520f11d-968d-4f4f-bf57-d14369c0d746), via openFDA; the full label on DailyMed
What does the levofloxacin label say about amiodarone?
Levofloxacin label, warnings and precautionsLevofloxacin should be avoided in patients with known prolongation of the QT interval, patients with uncorrected hypokalemia, and patients receiving Class IA (quinidine, procainamide), or Class III (amiodarone, sotalol) antiarrhythmic agents.
Source: FDA drug label (Levofloxacin), Lupin Pharmaceuticals, Inc., effective July 10, 2024 (SPL set 4be13bd5-0c39-43c3-9232-b1226ccd4dbc), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Amiodarone | Levofloxacin | |
|---|---|---|
| Labeled for | n/a | Bacterial infections, Urinary tract infections |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.122 per tablet 200 mg tablet | $0.259 per tablet 750 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once