What the FDA labels say about taking them together
Amiodarone and iloperidone
Iloperidone's FDA label of May 6, 2026 names amiodarone in its warnings and precautions section; the amiodarone labels PlainMeds reads (2) do not name iloperidone.
Check it at the source: the amiodarone FDA label on DailyMed (effective December 9, 2025, Chartwell RX, LLC); the iloperidone FDA label on DailyMed (effective May 6, 2026, Vanda Pharmaceuticals Inc.).
What does the amiodarone label say about iloperidone?
Amiodarone's label (effective December 9, 2025) and its 1 other brand-application label do not name iloperidone in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Amiodarone Hydrochloride), Chartwell RX, LLC, effective December 9, 2025 (SPL set 5520f11d-968d-4f4f-bf57-d14369c0d746), via openFDA; the full label on DailyMed
What does the iloperidone label say about amiodarone?
Iloperidone label, warnings and precautionsThe use of FANAPT should be avoided in combination with other drugs that are known to prolong QTc including Class 1A (e.g., quinidine, procainamide) or Class III (e.g., amiodarone, sotalol) antiarrhythmic medications, antipsychotic medications (e.g., chlorpromazine, thioridazine), antibiotics (e.g., gatifloxacin, moxifloxacin), or any other class of medications known to prolong the QTc interval (e.g., pentamidine, levomethadyl acetate, methadone).
Source: FDA drug label (FANAPT), Vanda Pharmaceuticals Inc., effective May 6, 2026 (SPL set 33f60b40-3fca-11de-8f56-0002a5d5c51b), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Amiodarone | Iloperidone | |
|---|---|---|
| Labeled for | n/a | Schizophrenia, Bipolar disorder |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.122 per tablet 200 mg tablet | $60.01 per tablet 12 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once