What the FDA labels say about taking them together
Amiodarone and asenapine
Asenapine's FDA label of January 31, 2025 names amiodarone in its warnings and precautions section; the amiodarone labels PlainMeds reads (2) do not name asenapine.
Check it at the source: the amiodarone FDA label on DailyMed (effective December 9, 2025, Chartwell RX, LLC); the asenapine FDA label on DailyMed (effective January 31, 2025, Allergan, Inc.).
What does the amiodarone label say about asenapine?
Amiodarone's label (effective December 9, 2025) and its 1 other brand-application label do not name asenapine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Amiodarone Hydrochloride), Chartwell RX, LLC, effective December 9, 2025 (SPL set 5520f11d-968d-4f4f-bf57-d14369c0d746), via openFDA; the full label on DailyMed
What does the asenapine label say about amiodarone?
Asenapine label, warnings and precautionsThe use of SAPHRIS should be avoided in combination with other drugs known to prolong QTc including Class 1A antiarrhythmics (e.g., quinidine, procainamide) or Class 3 antiarrhythmics (e.g., amiodarone, sotalol), antipsychotic medications (e.g., ziprasidone, chlorpromazine, thioridazine), and antibiotics (e.g., gatifloxacin, moxifloxacin).
Source: FDA drug label (Secuado, NDA212268), Noven Therapeutics, LLC, effective January 30, 2025 (SPL set 685eaf44-5944-4f38-afba-0a4fc0b3462b), via openFDA
Source: FDA drug label (SAPHRIS), NDA022117 (Abbvie), as published by Allergan, Inc., effective January 31, 2025 (SPL set 5429f134-839f-4ffc-9944-55f51238def8), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Amiodarone | Asenapine | |
|---|---|---|
| Labeled for | n/a | Schizophrenia, Bipolar disorder |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.122 per tablet 200 mg tablet | $2.63 per tablet 10 mg tablet sl |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once