What the FDA labels say about taking them together
Amikacin and ethacrynic acid
Amikacin's FDA label of December 10, 2025 names ethacrynic acid in its boxed warning section; the ethacrynic acid label PlainMeds reads does not name amikacin. The amikacin label: “Avoid concomitant use of ARIKAYCE with ethacrynic acid, furosemide, urea, or intravenous mannitol.”
Check it at the source: the amikacin FDA label on DailyMed (effective December 10, 2025, Qilu Pharmaceutical Co., Ltd.); the ethacrynic acid FDA label on DailyMed (effective August 31, 2020, Bausch Health US, LLC).
What does the amikacin label say about ethacrynic acid?
Amikacin label, boxed warningThe concurrent use of amikacin with potent diuretics (ethacrynic acid, or furosemide) should be avoided since diuretics by themselves may cause ototoxicity.
Arikayce label (Insmed Incorporated, August 4, 2026), drug interactionsAvoid concomitant use of ARIKAYCE with ethacrynic acid, furosemide, urea, or intravenous mannitol.
Source: FDA drug label (Arikayce, NDA207356), Insmed Incorporated, effective August 4, 2026 (SPL set 499ab990-2b21-474f-aaba-d86388965f40), via openFDA
Source: FDA drug label (Amikacin Sulfate), Qilu Pharmaceutical Co., Ltd., effective December 10, 2025 (SPL set 20fa61ef-11e2-4d01-82ea-b5412cefaead), via openFDA; the full label on DailyMed
What does the ethacrynic acid label say about amikacin?
Ethacrynic acid's label (effective August 31, 2020) does not name amikacin in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (EDECRIN), Bausch Health US, LLC, effective August 31, 2020 (SPL set 1efe378e-fee1-4ae9-8ea5-0fe2265fe2d8), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Amikacin | Ethacrynic acid | |
|---|---|---|
| Labeled for | Bacterial infections | Edema (fluid retention), Heart failure |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $2.33 per mL 500 mg/2 mL vial | $0.807 per tablet 25 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once