Prescription medication · Antiplatelet / Vasodilator

dipyridamole

Also sold as Persantine. This medicine helps prevent blood clots after you have a heart valve replaced.

Data updated 2026-05-15

3,682
FDA reportsLightly reported
5
InteractionsFew interactions
$0.11
Generic price (NADAC)

What the data shows

dipyridamole (Persantine) is a prescription Antiplatelet / Vasodilator, among the least-reported drugs the FDA tracks (3,682 FDA reports), with 5 documented drug interactions.

Reporting volume reflects how widely a drug is used and studied, not how dangerous it is, a FAERS report documents a temporal association, never proof of cause.

dipyridamole (Persantine) is a prescription Antiplatelet / Vasodilator. This medicine helps prevent blood clots after you have a heart valve replaced.

Dipyridamole helps prevent blood clots after heart valve replacement. It works with other blood-thinning medicines.

Verify with FDA → · CMS NADAC pricing →

Drug Pricing (NADAC)

Generic Price

$0.11/unit

Generic Available

Yes (4 manufacturers)

Pricing data from NADAC (CMS), effective December 18, 2024. Compare all drug costs →

Compare with Another Drug → Full Side Effects Report →

What it does

This medicine helps prevent blood clots after you have a heart valve replaced.

Common side effects

Dizziness, Abdominal distress

Key warnings

Taking dipyridamole with certain medicines used for heart stress tests can increase the risk of heart-related side effects.

The sections below are summarized in plain English from dipyridamole's FDA-approved prescribing information. They describe what the official label says, and are not personal medical advice.

How It Works

Dipyridamole is an antiplatelet medicine. It helps to keep blood cells called platelets from sticking together and forming clots. This helps your blood flow more freely.

Side Effects (from patient reports)

Based on 3,682 FDA adverse event reports.

Most-reported reactions

Adverse reactions in FAERS for dipyridamole, by number of reports

reports

What this shows Bars show how often each reaction was reported, not how likely it is to happen, a report records a temporal association, never proof that the drug caused it.

Source FDA Adverse Event Reporting System (FAERS) As of 2025

Reports over time

Adverse-event reports filed for dipyridamole each year to the FDA Adverse Event Reporting System (FAERS).

0100200300400 200220062009201220152018202120242025 75

Year-to-year volume tracks usage, prescribing, and scrutiny, not a change in per-patient risk. Source: FDA FAERS.

Where dipyridamole sits

dipyridamole has more FDA adverse-event reports than 21% of the drugs FAERS tracks. A high position reflects how widely a drug is used and watched, not how dangerous it is.

fewest reports most reports

Percentile across all drugs PlainMeds tracks by FAERS report volume. The dot is dipyridamole; the line is the median (50th percentile).

FDA Adverse Event Report Analysis

Detailed analysis of 3,682 reports from the FDA Adverse Event Reporting System (FAERS). Reports span 2002–2025.

Total Reports

3,682

Reports Mentioning Death

459

12.5% of reports — not proof of cause

Hospitalization Reports

1,894

Top Indication

Product Used For Unknown Indication

Gender Distribution

Female 1,700 (53%)
Male 1,453 (46%)

Age Distribution

0–17 205
18–44 162
45–64 575
65–74 610
75+ 1,235

Most Reported Adverse Reactions (FAERS)

# Reaction Reports
1 FALL 545
2 HYPOTENSION 531
3 PAIN 516
4 COGNITIVE DISORDER 497
5 DEPRESSED LEVEL OF CONSCIOUSNESS 471
6 CONSTIPATION 467
7 ORTHOSTATIC HYPOTENSION 464
8 BALANCE DISORDER 462
9 SEDATION COMPLICATION 449
10 BLOOD CALCIUM DECREASED 441
11 CREATININE RENAL CLEARANCE DECREASED 441
12 MOBILITY DECREASED 440
13 SEDATION 434
14 TOXICITY TO VARIOUS AGENTS 385
15 DYSPNOEA 241

Reactions in Death Reports

DEATH 73
PNEUMONIA 37
CEREBRAL HAEMORRHAGE 29
CEREBROVASCULAR ACCIDENT 29
RENAL FAILURE 27
MULTI-ORGAN FAILURE 25
SEPSIS 25
EMBOLISM 22
DIARRHOEA 19
NEUROLOGICAL SYMPTOM 19

Reactions in Hospitalization Reports

FALL 525
HYPOTENSION 484
COGNITIVE DISORDER 479
PAIN 462
DEPRESSED LEVEL OF CONSCIOUSNESS 459
ORTHOSTATIC HYPOTENSION 456
CONSTIPATION 455
BALANCE DISORDER 449
SEDATION COMPLICATION 446
BLOOD CALCIUM DECREASED 435

Source: FDA FAERS (Adverse Event Reporting System) Reports are voluntary and do not establish causation

Serious Warnings

Taking dipyridamole with certain medicines used for heart stress tests can increase the risk of heart-related side effects. Make sure your doctor knows you are taking dipyridamole before any stress test.

Known Drug Interactions

moderate heparin

7.2 Platelet Inhibitors Drugs such as NSAIDS (including salicylic acid, ibuprofen, indomethacin, and celecoxib), dextran, phenylbutazone, thienopyridines, dipyridamole, hydroxychloroquine, glycoprotein IIb/IIIa antagonists (including abciximab, eptifibatide, and tirofiban), and others that interfere with platelet-aggregation reactions (the main hemostatic defense of heparinized patients) may induce bleeding and should be used with caution in patients receiving heparin sodium.

Mechanism: These drugs both interfere with how your blood clots, making it more likely that you will bleed. Dipyridamole stops blood cells from clumping together while heparin works as a blood thinner.

moderate warfarin

Table 3: Drugs that Can Increase the Risk of Bleeding Drug Class Specific Drugs Anticoagulants argatroban, dabigatran, bivalirudin, desirudin, heparin, lepirudin Antiplatelet Agents aspirin, cilostazol, clopidogrel, dipyridamole, prasugrel, ticlopidine Non-steroidal Anti-Inflammatory Agents celecoxib, diclofenac, diflunisal, fenoprofen, ibuprofen, indomethacin, ketoprofen, ketorolac, mefenamic acid, naproxen, oxaprozin, piroxicam, sulindac Serotonin Reuptake Inhibitors citalopram, desvenlafaxine, duloxetine, escitalopram, fluoxetine, fluvoxamine, milnacipran, paroxetine, sertraline,...

Mechanism: These medicines both thin the blood in different ways. Using them at the same time can lead to a higher chance of bruising or bleeding.

minor adenosine

Adenosinergic agents (e.g., adenosine, regadenoson) Dipyridamole has been reported to increase the plasma levels and cardiovascular effects of adenosine. Adjustment of adenosine dosage may be necessary. Dipyridamole also increases the cardiovascular effects of regadenoson, an adenosine A 2A -receptor agonist.

Mechanism: Dipyridamole causes adenosine levels to build up in the blood, which can make the effects on your heart and blood vessels stronger.

minor enoxaparin

These agents include medications such as: anticoagulants, platelet inhibitors including acetylsalicylic acid, salicylates, NSAIDs (including ketorolac tromethamine), dipyridamole, or sulfinpyrazone.

Mechanism: These medicines both work to prevent blood clots in different ways, which can lead to an increased risk of bleeding when used together.

minor nicardipine

When therapeutic concentrations of furosemide, propranolol, dipyridamole, warfarin, quinidine or naproxen were added to human plasma (in vitro), the plasma protein binding of nicardipine hydrochloride capsules were not altered.

Mechanism: These drugs do not change how nicardipine attaches to proteins in the blood.

This is a plain-language summary of FDA-label interaction records and does not provide individual medication-combination directions.

Common Questions

Can I take aspirin with dipyridamole?
No, do not take aspirin with dipyridamole when you are also taking a coumarin anticoagulant like warfarin.
What should I tell my doctor before taking dipyridamole?
Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.
Can dipyridamole cause bleeding?
When taken with warfarin, dipyridamole does not usually increase bleeding more than warfarin alone. However, increased bleeding during or after surgery has been reported rarely.
What are the signs of an allergic reaction?
Signs of an allergic reaction may include rash, hives, severe trouble breathing, and swelling. Seek immediate medical attention if you experience these symptoms.
Can dipyridamole affect my liver?
Rarely, dipyridamole has been reported to cause liver problems. Contact your doctor if you develop symptoms like yellowing of the skin or eyes.
What if I experience persistent side effects?
If you have side effects that are bothersome or do not go away, talk to your doctor. They may need to adjust your dose or have you stop taking the medicine.
Does dipyridamole interact with other medications?
Yes, dipyridamole can interact with certain medicines, such as those used for heart stress tests and cholinesterase inhibitors. Be sure your doctor knows all the medicines you are taking.
How long will I need to take dipyridamole?
Your doctor will determine how long you need to take dipyridamole based on your specific situation. Follow your doctor's instructions carefully.
What does dipyridamole look like?
Dipyridamole tablets are light yellow, round, and film-coated. They come in different strengths (25 mg, 50 mg, and 75 mg).
What if I accidentally take too much dipyridamole?
If you take too much dipyridamole, call your doctor or go to the nearest emergency room right away.
What are the common side effects of dipyridamole?
The registry lists Dizziness, Abdominal distress among the most-reported FAERS reaction terms for dipyridamole. The compiled record contains 3,682 FDA adverse-event reports. These counts are not an individual symptom assessment.
Does dipyridamole interact with other medications?
The registry has 5 documented interaction rows for dipyridamole. Notable source-record pairings include heparin, warfarin, adenosine. These rows are not a complete medication review.
What drug class is dipyridamole?
dipyridamole belongs to the Antiplatelet / Vasodilator drug class. It requires a prescription (Rx). This medicine helps prevent blood clots after you have a heart valve replaced.
What pregnancy or breastfeeding source fields are listed for dipyridamole?
The FDA label for dipyridamole contains product-specific pregnancy or breastfeeding language. PlainMeds does not apply that source text to an individual.

Related Medications in Antiplatelet / Vasodilator

Other drugs grouped near dipyridamole - same-class peers and common alternatives.

apixaban

Eliquis

Apixaban (Eliquis) is a medicine that helps prevent blood clots.

Compare with dipyridamole →

aspirin

Bayer, Ecotrin

Aspirin is a common medicine used to relieve minor pain.

Compare with dipyridamole →

cilostazol

Pletal

Cilostazol is a medicine that helps improve walking distance in people with leg pain due to poor circulation.

Compare with dipyridamole →

clopidogrel

Plavix

Clopidogrel is a drug that helps to prevent blood clots.

Compare with dipyridamole →

dabigatran

Pradaxa

Dabigatran (Pradaxa) is a drug that helps to prevent blood clots from forming.

Compare with dipyridamole →

Compare dipyridamole vs apixaban side-by-side →

Compare beyond drug class

Nationwide peers by FAERS volume & death-report share

Two PlainMeds-derived comparison paths for dipyridamole: nearest FDA FAERS report volume and nearest death-report share among drugs with at least 1,000 logged reports, excluding same-class neighbors listed above. Counts reflect reporting volume, not proven individual harm.

Similar FAERS report volume

Nearest drugs by total FAERS reports. This record: 3,682.

4 peers

Similar death-report share

Nearest drugs by FAERS death-report share. This record: 12.47%.

4 peers

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What the FDA Data Shows for dipyridamole

The FDA label for dipyridamole (sold under brand names such as Persantine) classifies it as a prescription-only medication in the Antiplatelet / Vasodilator class. This medicine helps prevent blood clots after you have a heart valve replaced. Official labeling lists 2 commonly reported side effects, including Dizziness, Abdominal distress.

Post-market surveillance from the FDA Adverse Event Reporting System (FAERS) captures real-world experience. For this drug, FAERS contains 3,682 voluntary reports. The database also lists 5 documented drug interactions derived from FDA labeling, with the top-flagged interaction rated moderate severity. NADAC pricing from CMS shows a generic unit cost of $0.11.

Report counts do not establish causation, a FAERS entry documents a temporal association, not proof that the drug produced the outcome. Widely prescribed medications naturally accumulate more reports than niche therapies, so raw totals must be interpreted alongside total exposure. Shortage status, recall history, and patent information are separate source-record fields. This page is a public FDA/CMS registry and does not provide medical, treatment, substitution, or medication-change directions.

Data Sources

Drug labeling: FDA Drug Labels (SPL/DailyMed). Adverse events: FDA Adverse Event Reporting System (FAERS). Pricing: CMS National Average Drug Acquisition Cost (NADAC).

FAERS reports are voluntary and do not establish causation. Drug interactions are derived from FDA labeling and clinical references. This registry does not provide medication decisions.

Last updated: September 16, 2023

PlainMeds is rendered directly from FDA openFDA/FAERS extracts, DailyMed labels, and CMS drug-pricing files, no number is typed in by an editor. FAERS counts, recalls, shortages, and price figures on this page are queried live from those federal extracts. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error. Data current as of 2026-05-15. Primary sources: openFDA / FAERS, DailyMed and CMS Part B ASP.

Read our methodology - how this data is sourced, computed, and verified.

Data currency: FDA FAERS adverse-event reports through 2025, CMS NADAC acquisition-cost pricing effective December 2024, compiled from the source snapshot dated . See our methodology for per-source dates and refresh cadence. Spot a figure that looks wrong? Report a data issue.

All federal data sources used on this page