Prescription medication · Oxazolidinone Antibiotic

tedizolid

Also sold as Sivextro. Tedizolid treats acute bacterial skin infections.

Data updated 2026-05-15

322
FDA reports
2
InteractionsFew interactions
Rx
Availability

What the data shows

tedizolid (Sivextro) is a prescription Oxazolidinone Antibiotic, with 322 FDA adverse-event reports on file, with 2 documented drug interactions.

Reporting volume reflects how widely a drug is used and studied, not how dangerous it is, a FAERS report documents a temporal association, never proof of cause.

tedizolid (Sivextro) is a prescription Oxazolidinone Antibiotic. Tedizolid treats acute bacterial skin infections.

Tedizolid (Sivextro) is an antibiotic medicine. It fights certain bacteria that cause skin infections.

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What it does

Tedizolid treats acute bacterial skin infections.

Common side effects

Nausea, Headache, Diarrhea

Key warnings

If you have a low white blood cell count (neutropenia), talk to your doctor.

The sections below are summarized in plain English from tedizolid's FDA-approved prescribing information. They describe what the official label says, and are not personal medical advice.

How It Works

Tedizolid belongs to a class of drugs called oxazolidinones. It stops bacteria from growing by blocking their ability to make proteins. This helps your body fight off the infection.

Side Effects (from patient reports)

Based on 322 FDA adverse event reports.

Most-reported reactions

Adverse reactions in FAERS for tedizolid, by number of reports

reports

What this shows Bars show how often each reaction was reported, not how likely it is to happen, a report records a temporal association, never proof that the drug caused it.

Source FDA Adverse Event Reporting System (FAERS)

Serious Warnings

If you have a low white blood cell count (neutropenia), talk to your doctor. Tedizolid may not work as well. Diarrhea can happen while taking tedizolid or even months after. Tell your doctor right away if you get diarrhea.

Known Drug Interactions

minor rosuvastatin

If coadministration cannot be avoided, monitor for adverse reactions related to the concomitantly administered BCRP substrates, including rosuvastatin.

Mechanism: Tedizolid blocks a protein that helps clear rosuvastatin from your body, which can lead to higher levels of the drug.

minor methotrexate

If possible, an interruption in the treatment of the co-administered BCRP substrate medicinal product should be considered during treatment with SIVEXTRO, especially for BCRP substrates with a narrow therapeutic index (e.g., methotrexate or topotecan).

Mechanism: Tedizolid stops a protein from moving methotrexate out of your body, which can cause the drug to build up to toxic levels.

This is a plain-language summary of FDA-label interaction records and does not provide individual medication-combination directions.

Common Questions

What if I am allergic to tedizolid?
Tell your doctor if you have had an allergic reaction to tedizolid or other similar antibiotics in the past.
Can I take tedizolid with other medicines?
Tedizolid can interact with some other medicines. Tell your doctor about all the medicines you take, including over-the-counter drugs and supplements.
How long does it take for tedizolid to work?
You should start feeling better within a few days. Finish all 6 days of medicine, even if you feel better.
What if my symptoms get worse?
Tell your doctor if your symptoms do not improve or if they get worse.
Can tedizolid cause a yeast infection?
Like other antibiotics, tedizolid can sometimes cause yeast infections. Talk to your doctor if you think you have a yeast infection.
Is it safe to drink alcohol while taking tedizolid?
Ask your doctor if it is safe to drink alcohol while taking tedizolid.
What should I do if I think I have a side effect?
Tell your doctor about any side effects you experience while taking tedizolid.
Can I drive or operate machinery while taking tedizolid?
Tedizolid can cause dizziness. Be careful driving or operating machinery until you know how it affects you.
Do I need any special tests while taking tedizolid?
Your doctor may order blood tests to monitor your liver function and blood cell counts.
What if I still have questions about tedizolid?
Talk to your doctor or pharmacist if you have any other questions about tedizolid.
What are the common side effects of tedizolid?
The registry lists Nausea, Headache, Diarrhea, Vomiting, Dizziness among the most-reported FAERS reaction terms for tedizolid. The compiled record contains 322 FDA adverse-event reports. These counts are not an individual symptom assessment.
Does tedizolid interact with other medications?
The registry has 2 documented interaction rows for tedizolid. Notable source-record pairings include rosuvastatin, methotrexate. These rows are not a complete medication review.
What drug class is tedizolid?
tedizolid belongs to the Oxazolidinone Antibiotic drug class. It requires a prescription (Rx). Tedizolid treats acute bacterial skin infections.
What pregnancy or breastfeeding source fields are listed for tedizolid?
The FDA label for tedizolid contains product-specific pregnancy or breastfeeding language. PlainMeds does not apply that source text to an individual.

Related Medications in Oxazolidinone Antibiotic

Other drugs grouped near tedizolid - same-class peers and common alternatives.

amikacin

Amikin

Amikacin is an antibiotic medicine.

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amoxicillin

Amoxil

Amoxicillin and Clavulanate Potassium is a combination medicine used to fight bacterial infections.

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amoxicillin/clavulanate

Augmentin

Augmentin is a combination of two medicines, amoxicillin and clavulanate.

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ampicillin/sulbactam

Unasyn

Unasyn is a combination of two antibiotics that fights bacteria in your body.

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azithromycin

Zithromax, Z-Pack

Azithromycin is an antibiotic that fights bacteria.

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Compare tedizolid vs amikacin side-by-side →

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What the FDA Data Shows for tedizolid

The FDA label for tedizolid (sold under brand names such as Sivextro) classifies it as a prescription-only medication in the Oxazolidinone Antibiotic class. Tedizolid treats acute bacterial skin infections. Official labeling lists 6 commonly reported side effects, including Nausea, Headache, Diarrhea.

Post-market surveillance from the FDA Adverse Event Reporting System (FAERS) captures real-world experience. For this drug, FAERS contains 322 voluntary reports. The database also lists 2 documented drug interactions derived from FDA labeling, with the top-flagged interaction rated minor severity. Acquisition-cost data is surveyed weekly by CMS and updated as manufacturers report changes.

Report counts do not establish causation, a FAERS entry documents a temporal association, not proof that the drug produced the outcome. Widely prescribed medications naturally accumulate more reports than niche therapies, so raw totals must be interpreted alongside total exposure. Shortage status, recall history, and patent information are separate source-record fields. This page is a public FDA/CMS registry and does not provide medical, treatment, substitution, or medication-change directions.

Data Sources

Drug labeling: FDA Drug Labels (SPL/DailyMed). Adverse events: FDA Adverse Event Reporting System (FAERS).

FAERS reports are voluntary and do not establish causation. Drug interactions are derived from FDA labeling and clinical references. This registry does not provide medication decisions.

Last updated: April 4, 2025

PlainMeds is rendered directly from FDA openFDA/FAERS extracts, DailyMed labels, and CMS drug-pricing files, no number is typed in by an editor. FAERS counts, recalls, shortages, and price figures on this page are queried live from those federal extracts. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error. Data current as of 2026-05-15. Primary sources: openFDA / FAERS, DailyMed and CMS Part B ASP.

Read our methodology - how this data is sourced, computed, and verified.

Data currency: FDA FAERS adverse-event reports through 2025, CMS NADAC acquisition-cost pricing effective December 2024, compiled from the source snapshot dated . See our methodology for per-source dates and refresh cadence. Spot a figure that looks wrong? Report a data issue.

All federal data sources used on this page