Prescription medication · Oxazolidinone Antibiotic
tedizolid
Also sold as Sivextro. Tedizolid treats acute bacterial skin infections.
Data updated 2026-05-15
- 322
- FDA reports
- 2
- InteractionsFew interactions
- Rx
- Availability
What the data shows
tedizolid (Sivextro) is a prescription Oxazolidinone Antibiotic, with 322 FDA adverse-event reports on file, with 2 documented drug interactions.
Reporting volume reflects how widely a drug is used and studied, not how dangerous it is, a FAERS report documents a temporal association, never proof of cause.
tedizolid (Sivextro) is a prescription Oxazolidinone Antibiotic. Tedizolid treats acute bacterial skin infections.
Tedizolid (Sivextro) is an antibiotic medicine. It fights certain bacteria that cause skin infections.
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What it does
Tedizolid treats acute bacterial skin infections.
Common side effects
Nausea, Headache, Diarrhea
Key warnings
If you have a low white blood cell count (neutropenia), talk to your doctor.
The sections below are summarized in plain English from tedizolid's FDA-approved prescribing information. They describe what the official label says, and are not personal medical advice.
How It Works
Tedizolid belongs to a class of drugs called oxazolidinones. It stops bacteria from growing by blocking their ability to make proteins. This helps your body fight off the infection.
How to Take It
For adults, the dose is 200 mg once a day for 6 days. You can take it as a pill or through an IV. You can take the pill with or without food. For children, the dose depends on their weight.
This is a plain-language summary of tedizolid's FDA labeling, not individualized dosing advice. Ask a pharmacist or prescriber before changing how you take this medication.
Pregnancy & Breastfeeding
Tedizolid may harm your unborn baby. Tell your doctor if you are pregnant or plan to become pregnant. It is not known if tedizolid passes into breast milk, so talk to your doctor about breastfeeding.
This is a plain-language summary of tedizolid's FDA labeling, not individualized advice. Ask a pharmacist or prescriber about pregnancy or breastfeeding on this medication.
Missed Dose
If you miss a dose, take it as soon as you remember. If it is close to your next dose, skip the missed dose and continue with your regular schedule.
This is a plain-language summary of tedizolid's FDA labeling, not individualized advice. Ask a pharmacist or prescriber what to do about your specific missed dose.
Storage
Store tedizolid tablets and injection vials at room temperature, between 68°F and 77°F.
Side Effects (from patient reports)
Based on 322 FDA adverse event reports.
Most-reported reactions
Adverse reactions in FAERS for tedizolid, by number of reports
- Thrombocytopenia
Thrombocytopenia
60 reports
- Anaemia
Anaemia
45 reports
- Nausea
Nausea
43 reports
- Product Availability Issue
Product Availability Issue
33 reports
- Pancytopenia
Pancytopenia
30 reports
- Diarrhoea
Diarrhoea
26 reports
- Rash
Rash
25 reports
- Vomiting 21
Vomiting
21 reports
- Serotonin Syndrome 20
Serotonin Syndrome
20 reports
- Death 19
Death
19 reports
What this shows Bars show how often each reaction was reported, not how likely it is to happen, a report records a temporal association, never proof that the drug caused it.
Serious Warnings
If you have a low white blood cell count (neutropenia), talk to your doctor. Tedizolid may not work as well. Diarrhea can happen while taking tedizolid or even months after. Tell your doctor right away if you get diarrhea.
Known Drug Interactions
If coadministration cannot be avoided, monitor for adverse reactions related to the concomitantly administered BCRP substrates, including rosuvastatin.
Mechanism: Tedizolid blocks a protein that helps clear rosuvastatin from your body, which can lead to higher levels of the drug.
What to do: Your doctor should monitor you for any side effects related to your cholesterol medication.
If possible, an interruption in the treatment of the co-administered BCRP substrate medicinal product should be considered during treatment with SIVEXTRO, especially for BCRP substrates with a narrow therapeutic index (e.g., methotrexate or topotecan).
Mechanism: Tedizolid stops a protein from moving methotrexate out of your body, which can cause the drug to build up to toxic levels.
What to do: Your doctor might have you stop taking methotrexate for a short time while you finish your antibiotic treatment.
This is a plain-language summary of interactions documented in FDA labeling, not individualized advice. Ask a pharmacist or prescriber before combining medications.
Common Questions
What if I am allergic to tedizolid?
Can I take tedizolid with other medicines?
How long does it take for tedizolid to work?
What if my symptoms get worse?
Can tedizolid cause a yeast infection?
Is it safe to drink alcohol while taking tedizolid?
What should I do if I think I have a side effect?
Can I drive or operate machinery while taking tedizolid?
Do I need any special tests while taking tedizolid?
What if I still have questions about tedizolid?
What are the common side effects of tedizolid?
Does tedizolid interact with other medications?
What drug class is tedizolid?
Is tedizolid safe during pregnancy?
Related Medications in Oxazolidinone Antibiotic
Other drugs grouped near tedizolid - same-class peers and common alternatives.
amikacin
Amikin
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amoxicillin
Amoxil
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amoxicillin/clavulanate
Augmentin
Augmentin is a combination of two medicines, amoxicillin and clavulanate.
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ampicillin/sulbactam
Unasyn
Unasyn is a combination of two antibiotics that fights bacteria in your body.
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azithromycin
Zithromax, Z-Pack
Azithromycin is an antibiotic that fights bacteria.
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Medication Guides
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Common Drug Interactions
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What the FDA Data Shows for tedizolid
The FDA label for tedizolid (sold under brand names such as Sivextro) classifies it as a prescription-only medication in the Oxazolidinone Antibiotic class. Tedizolid treats acute bacterial skin infections. Official labeling lists 6 commonly reported side effects, including Nausea, Headache, Diarrhea.
Post-market surveillance from the FDA Adverse Event Reporting System (FAERS) captures real-world experience. For this drug, FAERS contains 322 voluntary reports. The database also lists 2 documented drug interactions derived from FDA labeling, with the top-flagged interaction rated minor severity. Acquisition-cost data is surveyed weekly by CMS and updated as manufacturers report changes.
Report counts do not establish causation, a FAERS entry documents a temporal association, not proof that the drug produced the outcome. Widely prescribed medications naturally accumulate more reports than niche therapies, so raw totals must be interpreted alongside total exposure. Shortage status, recall history, and patent information further shape supply and switching decisions. This page summarizes public FDA data for educational purposes only and is not a substitute for professional medical advice, always consult a licensed healthcare provider before starting, stopping, or changing any medication.
Data Sources
Drug labeling: FDA Drug Labels (SPL/DailyMed). Adverse events: FDA Adverse Event Reporting System (FAERS).
FAERS reports are voluntary and do not establish causation. Drug interactions are derived from FDA labeling and clinical references. Always consult a healthcare professional before making medication decisions.
Last updated: April 4, 2025
Read our methodology - how this data is sourced, computed, and verified.
Data currency: FDA FAERS adverse-event reports through 2025, CMS NADAC acquisition-cost pricing effective December 2024, compiled and last refreshed May 2026. See our methodology for per-source dates and refresh cadence. Spot a figure that looks wrong? Report a correction.
All federal data sources used on this page
- FDA Orange Book - approved drug products with therapeutic equivalence. accessdata.fda.gov/cder/ob
- FDA DailyMed - NIH-hosted drug labeling for FDA-approved meds. dailymed.nlm.nih.gov
- FDA Adverse Event Reporting System (FAERS) - post-marketing safety surveillance. fda.gov/drugs/faers
- NLM RxNorm - standardized clinical drug nomenclature. nlm.nih.gov/research/umls/rxnorm
- CMS Medicare Part B Drug Average Sales Price Files - federal drug pricing data. cms.gov/medicare/part-b-drugs/asp
- FDA Drug Shortages Database - current and resolved drug shortage tracking. accessdata.fda.gov/drugshortages