What the label lists and what reports show

Prochlorperazine side effects

Prochlorperazine's FDA label lists its adverse reactions in its own words. FAERS holds 37,667 reports naming it through July 30, 2026; the reaction reported most often, leaving out the conditions it is used for, product-use terms and outcomes, is fatigue (4,189 reports).

Generic listed
Boxed warning

Check it at the source: the prochlorperazine FDA label on DailyMed (effective January 27, 2026, GLENMARK PHARMACEUTICALS INC., USA); the FDA FAERS public dashboard.

What does the label list?

From the label: adverse reactions
Drowsiness, dizziness, amenorrhea, blurred vision, skin reactions and hypotension may occur. Neuroleptic Malignant Syndrome (NMS) has been reported in association with antipsychotic drugs (see WARNINGS ). Cholestatic jaundice has occurred. If fever with grippe-like symptoms occurs, appropriate liver studies should be conducted. If tests indicate an abnormality, stop treatment. There have been a few observations of fatty changes in the livers of patients who have died while receiving the drug. No causal relationship has been established. Leukopenia and agranulocytosis have occurred. Warn patients to report the sudden appearance of sore throat or other signs of infection. If white blood cell and differential counts indicate leukocyte depression, stop treatment and start antibiotic and other suitable therapy. …

Source: FDA drug label, GLENMARK PHARMACEUTICALS INC., USA, effective January 27, 2026 (SPL set 9c806152-70d0-43eb-b183-b51b12b82b31), via openFDA; the full label on DailyMed

What do FAERS reports show?

37,667 reports list prochlorperazine among the medicines taken, each a report of something that happened, not proof the medicine caused it; 5,182 are coded as a death and 15,323 as a hospital stay. Counts follow how widely a medicine is used and watched, and they are not a measure of how risky it is. Of the 19 reactions below, 3 are named by the same term (in US spelling) in the label's adverse reactions, warnings or patient leaflet; a reaction the label does not name may still be there under another word, and a report does not show that the medicine caused it.

Reports received each year

The 25 most reported reactions

Nausea (a use or a product term, not a reaction)4,814
Fatigue4,189
Diarrhoea3,438
Vomiting (a use or a product term, not a reaction)2,631
Death (an outcome recorded in the report)2,510
Febrile Neutropenia2,077
Off Label Use (a use or a product term, not a reaction)1,930
Asthenia1,895
Pneumonia1,615
Dyspnoea1,596
Decreased Appetite1,592
Pain1,465
Pyrexia1,408
Headache (named in the label)1,407
Constipation (named in the label)1,400
Dizziness (named in the label)1,368
Rash1,249
Malaise1,175
Weight Decreased1,172
Dehydration1,129
Drug Ineffective (a use or a product term, not a reaction)1,084
Disease Progression (a use or a product term, not a reaction)1,075
Fall1,010
Abdominal Pain993
Platelet Count Decreased974

Source: FDA Adverse Event Reporting System (FAERS) via openFDA, reports through July 30, 2026; reactions as MedDRA preferred terms

What next?

Prochlorperazine: the full record: label, generics, price, shortages, recalls
Report a side effect to the FDA: MedWatch
Side effects hub: the most reported medicines and reactions