Prescription medicine
Lanthanum Brand names: Fosrenol
Lanthanum (Fosrenol) is a prescription medicine with an FDA approval on record since 2004. FDA's NDC Directory lists it from 5 generic labelers, and pharmacies paid $3.15 per tablet (Lanthanum carb 1,000 mg tablet chw) in the October 7, 2026 NADAC survey.
- Generic listed
Check it at the source: the lanthanum FDA label on DailyMed (effective December 31, 2024, Takeda Pharmaceuticals America, Inc.); the NDA 21468 record on Drugs@FDA; every lanthanum label on DailyMed.
Highlights of the record
FDA label of December 31, 2024; NDC Directory, Drugs@FDA and Orange Book, October 8, 2026; NADAC October 7, 2026
Used for
From the label: indications and usageFOSRENOL ® is a phosphate binder indicated to reduce serum phosphate in patients with end-stage renal disease (ESRD).
Forms and strengths
- 500 mg
- 750 mg
- 1000 mg
Chewable tablet; powder.
On the market
- Earliest approval on file
- October 26, 2004 Fosrenol, Takeda Pharms Usa; Drugs@FDA’s file, where older or withdrawn approvals can be missing
- Generic approvals
- 4 first August 11, 2017; 4 with a marketed status in Drugs@FDA
- Labelers listed (NDC)
- 7 of which 5 under generic applications, 1 under brand applications, repackagers included
- Last listed patent
- December 1, 2030 Fosrenol powder; not a generic launch date
Supply and safety
- Pharmacy cost (NADAC)
- $3.15 per tablet Lanthanum carb 1,000 mg tablet chw
- Shortage (FDA)
- No current entry
- Recalls by its makers (FDA)
- 4 since 2024 0 Class I among all firms' recalls; latest October 24, 2025
- FAERS reports
- 5,090 through July 30, 2026
What is lanthanum used for?
From the label: indications and usageFOSRENOL ® is a phosphate binder indicated to reduce serum phosphate in patients with end-stage renal disease (ESRD). Management of elevated serum phosphorus levels in patients with ESRD usually includes all of the following: reduction in dietary intake of phosphate, removal of phosphate by dialysis, and reduction of intestinal phosphate absorption with phosphate binders. FOSRENOL is a phosphate binder indicated to reduce serum phosphate in patients with end-stage renal disease (ESRD).
FDA pharmacologic class: Phosphate Binder.
Source: FDA drug label (Fosrenol), Takeda Pharmaceuticals America, Inc., effective December 31, 2024 (SPL set f10776b2-2c25-4343-aabe-68f302e5cb54), via openFDA; the full label on DailyMed
What does the patient leaflet for lanthanum say first?
The FDA-approved Medication Guide or Patient Information that comes with the medicine, in its own words.
From the patient leaflet: What is the most important information I should know about FOSRENOL?FOSRENOL may cause a bowel blockage, a hole in the bowel, or severe constipation, which can be serious, and sometimes lead to surgery or treatment in a hospital. You may have a higher risk of bowel blockage, a hole in the bowel, or severe constipation if you take FOSRENOL and have: a history of surgery, ulcers or cancer in the stomach or bowel a history of bowel blockage, or problems resulting in a decreased movement of food through your stomach and bowel (e.g., feeling full quickly after eating or constipation) an infection or inflammation of the stomach/bowel (peritonitis) Do not swallow FOSRENOL Chewable Tablets whole. Chew tablets completely before swallowing. If you cannot chew tablets completely, you may crush the tablets thoroughly before swallowing or discuss the oral powder formulation with your healthcare provider.
From the patient leaflet: How should I store FOSRENOL?Store FOSRENOL between 59°F to 86°F (15°C to 30°C). Keep FOSRENOL and all medicines out of the reach of children.
Source: FDA drug label (Fosrenol), Takeda Pharmaceuticals America, Inc., effective December 31, 2024 (SPL set f10776b2-2c25-4343-aabe-68f302e5cb54), via openFDA; the full label on DailyMed
Is there a generic for lanthanum (Fosrenol)?
The FDA approved the first generic lanthanum on August 11, 2017. 4 generic applications are approved; 4 of them carry a current (not discontinued) marketing status in Drugs@FDA; that status is not evidence that the generic is on sale.
FDA's NDC Directory lists lanthanum from 5 labelers under a generic (ANDA) application and from 1 brand labeler. A listing means the company has registered the product for sale; it does not show that every pharmacy stocks it.
The Orange Book lists no patent for Fosrenol tablets; a patent listed only for Fosrenol powder runs to December 1, 2030. A patent or exclusivity date is not the date a generic goes on sale: court cases and settlements move it either way.
- 2004 earliest approval on file
- 2017 first generic approved
- 2030 last listed patent
- red ticks recalls
Source: Drugs@FDA, FDA NDC Directory and the Orange Book (openFDA bulk files, October 8, 2026)
What do pharmacies pay for lanthanum (Fosrenol)?
In CMS's NADAC survey of October 7, 2026, pharmacies paid $3.15 per tablet (Lanthanum carb 1,000 mg tablet chw), down 27% from $4.29 on October 8, 2025. The chart's scale runs from the lowest to the highest price shown, not from zero. NADAC is what retail pharmacies paid their wholesalers, per unit, in CMS's monthly survey; what a patient pays depends on insurance and the pharmacy.
- Lanthanum carb 1,000 mg tablet chw (generic)
| Strength and form | Brand or generic | Pharmacy cost | 30 tablets, or one pen or vial | 12-month change |
|---|---|---|---|---|
| Lanthanum carb 1,000 mg tablet chw | Generic | $3.15 per tablet | $94.54 | -27% |
| Lanthanum carb 500 mg tablet chewable | Generic | $3.18 per tablet | $95.49 | -11% |
Source: CMS National Average Drug Acquisition Cost (NADAC) survey, October 7, 2026: what retail pharmacies paid per unit; not a counter price
Has lanthanum been recalled?
The FDA's Enforcement Report lists 4 recalls naming lanthanum since 2024: 0 Class I (the most serious), 4 Class II, 0 Class III; 4 still ongoing. A recall names products and lots, not every product of the medicine.
| Started | Class | Company | Reason |
|---|---|---|---|
| October 24, 2025 | Class II | Cipla USA, Inc. | Failed stability specifications: Out of specification for hardness test |
| October 23, 2024 | Class II | Cipla USA, Inc. | Failed Tablet/Capsule Specifications: Complaints received of crushed and broken tablets. |
Source: FDA Enforcement Report (drug recalls) via openFDA, through October 8, 2026
What does the lanthanum label say about other medicines?
The lanthanum label names 3 other medicines in its interaction, contraindication or warning sections. The labels of 3 other medicines name lanthanum. The sentences are the labels' own; a label lists what its studies and reports found, not every interaction.
| Medicine named | Section | What the label says |
|---|---|---|
| Ampicillin | drug interactions | … compounds where antacids have been demonstrated to reduce bioavailability include antibiotics (such as quinolones, ampicillin, and tetracyclines), thyroid hormones, ACE inhibitors, statin lipid regulators, and anti-malarials. |
| Ciprofloxacin | drug interactions | The bioavailability of oral ciprofloxacin was decreased by approximately 50% when taken with FOSRENOL in a single-dose study in healthy volunteers. |
| Levothyroxine | drug interactions | The bioavailability of levothyroxine was decreased by approximately 40% when taken together with FOSRENOL. |
Other labels that name lanthanum
Source: FDA drug label (Fosrenol), Takeda Pharmaceuticals America, Inc., effective December 31, 2024 (SPL set f10776b2-2c25-4343-aabe-68f302e5cb54), via openFDA; the full label on DailyMed
What do FAERS reports show for lanthanum?
The FDA Adverse Event Reporting System holds 5,090 reports that list lanthanum among the medicines taken, through July 30, 2026, each a report of something that happened, not proof the medicine caused it; 1,590 are coded as a death and 2,508 as a hospital stay. Counts follow how widely a medicine is used and watched, and they are not a measure of how risky it is.
Reports received each year
The most reported reactions
Source: FDA Adverse Event Reporting System (FAERS) via openFDA, reports through July 30, 2026
What next?
- Other phosphate binders
- the pharmacologic class, with prices and generics
- Lanthanum side effects
- the label's list beside FAERS reports
- Check an interaction
- what two or more labels say about each other