Prescription medication · Antiplatelet / Vasodilator
dipyridamole
Also sold as Persantine. This medicine helps prevent blood clots after you have a heart valve replaced.
Data updated 2026-05-15
- 3,682
- FDA reportsLightly reported
- 5
- InteractionsFew interactions
- $0.11
- Generic price (NADAC)
What the data shows
dipyridamole (Persantine) is a prescription Antiplatelet / Vasodilator, among the least-reported drugs the FDA tracks (3,682 FDA reports), with 5 documented drug interactions.
Reporting volume reflects how widely a drug is used and studied, not how dangerous it is, a FAERS report documents a temporal association, never proof of cause.
dipyridamole (Persantine) is a prescription Antiplatelet / Vasodilator. This medicine helps prevent blood clots after you have a heart valve replaced.
Dipyridamole helps prevent blood clots after heart valve replacement. It works with other blood-thinning medicines.
Verify with FDA → · CMS NADAC pricing →
Drug Pricing (NADAC)
Generic Price
$0.11/unit
Generic Available
Yes (4 manufacturers)
Pricing data from NADAC (CMS), effective December 18, 2024. Compare all drug costs →
What it does
This medicine helps prevent blood clots after you have a heart valve replaced.
Common side effects
Dizziness, Abdominal distress
Key warnings
Taking dipyridamole with certain medicines used for heart stress tests can increase the risk of heart-related side effects.
The sections below are summarized in plain English from dipyridamole's FDA-approved prescribing information. They describe what the official label says, and are not personal medical advice.
How It Works
Dipyridamole is an antiplatelet medicine. It helps to keep blood cells called platelets from sticking together and forming clots. This helps your blood flow more freely.
How to Take It
Take 75 to 100 mg of dipyridamole four times each day. Take it as directed by your doctor, along with your usual warfarin medicine. Do not take aspirin with coumarin anticoagulants like warfarin. Follow your doctor's instructions carefully.
This is a plain-language summary of dipyridamole's FDA labeling, not individualized dosing advice. Ask a pharmacist or prescriber before changing how you take this medication.
Pregnancy & Breastfeeding
Tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. It is not known if dipyridamole will harm your unborn baby or pass into breast milk.
This is a plain-language summary of dipyridamole's FDA labeling, not individualized advice. Ask a pharmacist or prescriber about pregnancy or breastfeeding on this medication.
Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule.
This is a plain-language summary of dipyridamole's FDA labeling, not individualized advice. Ask a pharmacist or prescriber what to do about your specific missed dose.
Storage
Store dipyridamole at room temperature, between 68°F and 77°F, away from light and moisture. Keep out of reach of children.
Side Effects (from patient reports)
Based on 3,682 FDA adverse event reports.
Most-reported reactions
Adverse reactions in FAERS for dipyridamole, by number of reports
- Falling
Falling
545 reports
- Low blood pressure
Low blood pressure
531 reports
- Pain
Pain
516 reports
- Problems with thinking or memory
Problems with thinking or memory
497 reports
- Reduced alertness
Reduced alertness
471 reports
- Difficulty pooping
Difficulty pooping
467 reports
- Low blood pressure upon standing
Low blood pressure upon standing
464 reports
- Problems with balance
Problems with balance
462 reports
- Problems with sleepiness
Problems with sleepiness
449 reports
- Low calcium levels in the blood
Low calcium levels in the blood
441 reports
What this shows Bars show how often each reaction was reported, not how likely it is to happen, a report records a temporal association, never proof that the drug caused it.
Reports over time
Adverse-event reports filed for dipyridamole each year to the FDA Adverse Event Reporting System (FAERS).
Year-to-year volume tracks usage, prescribing, and scrutiny, not a change in per-patient risk. Source: FDA FAERS.
Where dipyridamole sits
dipyridamole has more FDA adverse-event reports than 21% of the drugs FAERS tracks. A high position reflects how widely a drug is used and watched, not how dangerous it is.
Percentile across all drugs PlainMeds tracks by FAERS report volume. The dot is dipyridamole; the line is the median (50th percentile).
FDA Adverse Event Report Analysis
Detailed analysis of 3,682 reports from the FDA Adverse Event Reporting System (FAERS). Reports span 2002–2025.
Total Reports
3,682
Reports Mentioning Death
459
12.5% of reports — not proof of cause
Hospitalization Reports
1,894
Top Indication
Product Used For Unknown Indication
Gender Distribution
Age Distribution
Most Reported Adverse Reactions (FAERS)
| # | Reaction | Reports |
|---|---|---|
| 1 | FALL | 545 |
| 2 | HYPOTENSION | 531 |
| 3 | PAIN | 516 |
| 4 | COGNITIVE DISORDER | 497 |
| 5 | DEPRESSED LEVEL OF CONSCIOUSNESS | 471 |
| 6 | CONSTIPATION | 467 |
| 7 | ORTHOSTATIC HYPOTENSION | 464 |
| 8 | BALANCE DISORDER | 462 |
| 9 | SEDATION COMPLICATION | 449 |
| 10 | BLOOD CALCIUM DECREASED | 441 |
| 11 | CREATININE RENAL CLEARANCE DECREASED | 441 |
| 12 | MOBILITY DECREASED | 440 |
| 13 | SEDATION | 434 |
| 14 | TOXICITY TO VARIOUS AGENTS | 385 |
| 15 | DYSPNOEA | 241 |
Reactions in Death Reports
Reactions in Hospitalization Reports
Source: FDA FAERS (Adverse Event Reporting System) FDA FAERS (Adverse Event Reporting System) Reports are voluntary and do not establish causation
Serious Warnings
Taking dipyridamole with certain medicines used for heart stress tests can increase the risk of heart-related side effects. Make sure your doctor knows you are taking dipyridamole before any stress test.
Known Drug Interactions
7.2 Platelet Inhibitors Drugs such as NSAIDS (including salicylic acid, ibuprofen, indomethacin, and celecoxib), dextran, phenylbutazone, thienopyridines, dipyridamole, hydroxychloroquine, glycoprotein IIb/IIIa antagonists (including abciximab, eptifibatide, and tirofiban), and others that interfere with platelet-aggregation reactions (the main hemostatic defense of heparinized patients) may induce bleeding and should be used with caution in patients receiving heparin sodium.
Mechanism: These drugs both interfere with how your blood clots, making it more likely that you will bleed. Dipyridamole stops blood cells from clumping together while heparin works as a blood thinner.
What to do: Use these medications together with caution. Your healthcare provider should monitor you for bleeding risks.
Table 3: Drugs that Can Increase the Risk of Bleeding Drug Class Specific Drugs Anticoagulants argatroban, dabigatran, bivalirudin, desirudin, heparin, lepirudin Antiplatelet Agents aspirin, cilostazol, clopidogrel, dipyridamole, prasugrel, ticlopidine Non-steroidal Anti-Inflammatory Agents celecoxib, diclofenac, diflunisal, fenoprofen, ibuprofen, indomethacin, ketoprofen, ketorolac, mefenamic acid, naproxen, oxaprozin, piroxicam, sulindac Serotonin Reuptake Inhibitors citalopram, desvenlafaxine, duloxetine, escitalopram, fluoxetine, fluvoxamine, milnacipran, paroxetine, sertraline,...
Mechanism: These medicines both thin the blood in different ways. Using them at the same time can lead to a higher chance of bruising or bleeding.
What to do: Watch for unusual bleeding and tell your doctor immediately if it happens. Your healthcare provider may need to change your treatment plan.
Adenosinergic agents (e.g., adenosine, regadenoson) Dipyridamole has been reported to increase the plasma levels and cardiovascular effects of adenosine. Adjustment of adenosine dosage may be necessary. Dipyridamole also increases the cardiovascular effects of regadenoson, an adenosine A 2A -receptor agonist.
Mechanism: Dipyridamole causes adenosine levels to build up in the blood, which can make the effects on your heart and blood vessels stronger.
What to do: Your doctor may need to change your dose of adenosine if you are also taking dipyridamole.
These agents include medications such as: anticoagulants, platelet inhibitors including acetylsalicylic acid, salicylates, NSAIDs (including ketorolac tromethamine), dipyridamole, or sulfinpyrazone.
Mechanism: These medicines both work to prevent blood clots in different ways, which can lead to an increased risk of bleeding when used together.
What to do: Watch for signs of bleeding and ensure your healthcare provider is aware you are taking both medications.
When therapeutic concentrations of furosemide, propranolol, dipyridamole, warfarin, quinidine or naproxen were added to human plasma (in vitro), the plasma protein binding of nicardipine hydrochloride capsules were not altered.
Mechanism: These drugs do not change how nicardipine attaches to proteins in the blood.
What to do: No specific dose changes are required based on this information, but you should keep your doctor informed.
This is a plain-language summary of interactions documented in FDA labeling, not individualized advice. Ask a pharmacist or prescriber before combining medications.
Common Questions
Can I take aspirin with dipyridamole?
What should I tell my doctor before taking dipyridamole?
Can dipyridamole cause bleeding?
What are the signs of an allergic reaction?
Can dipyridamole affect my liver?
What if I experience persistent side effects?
Does dipyridamole interact with other medications?
How long will I need to take dipyridamole?
What does dipyridamole look like?
What if I accidentally take too much dipyridamole?
What are the common side effects of dipyridamole?
Does dipyridamole interact with other medications?
What drug class is dipyridamole?
Is dipyridamole safe during pregnancy?
Related Medications in Antiplatelet / Vasodilator
Other drugs grouped near dipyridamole - same-class peers and common alternatives.
apixaban
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aspirin
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cilostazol
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Cilostazol is a medicine that helps improve walking distance in people with leg pain due to poor circulation.
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clopidogrel
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Clopidogrel is a drug that helps to prevent blood clots.
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dabigatran
Pradaxa
Dabigatran (Pradaxa) is a drug that helps to prevent blood clots from forming.
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What the FDA Data Shows for dipyridamole
The FDA label for dipyridamole (sold under brand names such as Persantine) classifies it as a prescription-only medication in the Antiplatelet / Vasodilator class. This medicine helps prevent blood clots after you have a heart valve replaced. Official labeling lists 2 commonly reported side effects, including Dizziness, Abdominal distress.
Post-market surveillance from the FDA Adverse Event Reporting System (FAERS) captures real-world experience. For this drug, FAERS contains 3,682 voluntary reports. The database also lists 5 documented drug interactions derived from FDA labeling, with the top-flagged interaction rated moderate severity. NADAC pricing from CMS shows a generic unit cost of $0.11.
Report counts do not establish causation, a FAERS entry documents a temporal association, not proof that the drug produced the outcome. Widely prescribed medications naturally accumulate more reports than niche therapies, so raw totals must be interpreted alongside total exposure. Shortage status, recall history, and patent information further shape supply and switching decisions. This page summarizes public FDA data for educational purposes only and is not a substitute for professional medical advice, always consult a licensed healthcare provider before starting, stopping, or changing any medication.
Data Sources
Drug labeling: FDA Drug Labels (SPL/DailyMed). Adverse events: FDA Adverse Event Reporting System (FAERS). Pricing: CMS National Average Drug Acquisition Cost (NADAC).
FAERS reports are voluntary and do not establish causation. Drug interactions are derived from FDA labeling and clinical references. Always consult a healthcare professional before making medication decisions.
Last updated: September 16, 2023
Read our methodology - how this data is sourced, computed, and verified.
Data currency: FDA FAERS adverse-event reports through 2025, CMS NADAC acquisition-cost pricing effective December 2024, compiled and last refreshed May 2026. See our methodology for per-source dates and refresh cadence. Spot a figure that looks wrong? Report a correction.
All federal data sources used on this page
- FDA Orange Book - approved drug products with therapeutic equivalence. accessdata.fda.gov/cder/ob
- FDA DailyMed - NIH-hosted drug labeling for FDA-approved meds. dailymed.nlm.nih.gov
- FDA Adverse Event Reporting System (FAERS) - post-marketing safety surveillance. fda.gov/drugs/faers
- NLM RxNorm - standardized clinical drug nomenclature. nlm.nih.gov/research/umls/rxnorm
- CMS Medicare Part B Drug Average Sales Price Files - federal drug pricing data. cms.gov/medicare/part-b-drugs/asp
- FDA Drug Shortages Database - current and resolved drug shortage tracking. accessdata.fda.gov/drugshortages