Prescription medicine
Chenodiol Brand names: Ctexli; first approved as Chenix
Chenodiol (Ctexli) is a prescription medicine with an FDA approval on record since 1983. FDA's NDC Directory lists it from 1 generic labeler.
- Generic listed
Check it at the source: the chenodiol FDA label on DailyMed (effective December 16, 2025, Mirum Pharmaceuticals Inc.); the NDA 18513 record on Drugs@FDA; every chenodiol label on DailyMed.
Highlights of the record
FDA label of December 16, 2025; NDC Directory, Drugs@FDA and Orange Book, October 8, 2026
Used for
From the label: indications and usageCTEXLI is indicated for the treatment of cerebrotendinous xanthomatosis (CTX) in adults.
Forms and strengths
- 250 mg
Film-coated tablet.
On the market
- Earliest approval on file
- July 28, 1983 Chenix, Leadiant Biosci Inc; Drugs@FDA’s file, where older or withdrawn approvals can be missing
- Generic approvals
- 1 first October 22, 2009; 1 with a marketed status in Drugs@FDA
- Labelers listed (NDC)
- 2 of which 1 under generic applications, 1 under brand applications, repackagers included
Supply and safety
- Pharmacy cost (NADAC)
- Not in the survey
- Shortage (FDA)
- No current entry
- Recalls by its makers (FDA)
- No recall recorded
- FAERS reports
- 352 through July 30, 2026
What is chenodiol used for?
From the label: indications and usageCTEXLI is indicated for the treatment of cerebrotendinous xanthomatosis (CTX) in adults. CTEXLI is a bile acid indicated for treatment of cerebrotendinous xanthomatosis (CTX) in adults.
FDA pharmacologic class: Bile Acid.
Source: FDA drug label (CTEXLI), Mirum Pharmaceuticals Inc., effective December 16, 2025 (SPL set 015384e7-4ac5-4782-a309-e40cd1421c5b), via openFDA; the full label on DailyMed
Is there a generic for chenodiol (Ctexli)?
The FDA approved the first generic chenodiol on October 22, 2009. 1 generic application is approved; 1 of it carries a current (not discontinued) marketing status in Drugs@FDA; that status is not evidence that the generic is on sale.
FDA's NDC Directory lists chenodiol from 1 labeler under a generic (ANDA) application and from 1 brand labeler. A listing means the company has registered the product for sale; it does not show that every pharmacy stocks it.
- 1983 earliest approval on file
- 2009 first generic approved
Source: Drugs@FDA, FDA NDC Directory and the Orange Book (openFDA bulk files, October 8, 2026)
What does the chenodiol label say about other medicines?
The chenodiol label names 2 other medicines in its interaction, contraindication or warning sections. The sentences are the labels' own; a label lists what its studies and reports found, not every interaction.
| Medicine named | Section | What the label says |
|---|---|---|
| Cholestyramine | drug interactions | Drugs on CTEXLI Co-administration of bile acid sequestering agents, such as cholestyramine and colestipol, or aluminum-based antacids may decrease absorption of CTEXLI in the intestine and may result in decreased efficacy of CTEXLI. |
| Colestipol | drug interactions | Drugs on CTEXLI Co-administration of bile acid sequestering agents, such as cholestyramine and colestipol, or aluminum-based antacids may decrease absorption of CTEXLI in the intestine and may result in decreased efficacy of CTEXLI. |
Source: FDA drug label (CTEXLI), Mirum Pharmaceuticals Inc., effective December 16, 2025 (SPL set 015384e7-4ac5-4782-a309-e40cd1421c5b), via openFDA; the full label on DailyMed
What do FAERS reports show for chenodiol?
The FDA Adverse Event Reporting System holds 352 reports that list chenodiol among the medicines taken, through July 30, 2026, each a report of something that happened, not proof the medicine caused it; 21 are coded as a death and 28 as a hospital stay. Counts follow how widely a medicine is used and watched, and they are not a measure of how risky it is.
The most reported reactions
Source: FDA Adverse Event Reporting System (FAERS) via openFDA, reports through July 30, 2026
What next?
- Other bile acids
- the pharmacologic class, with prices and generics
- Chenodiol side effects
- the label's list beside FAERS reports
- Check an interaction
- what two or more labels say about each other