What the FDA labels say about taking them together
Chenodiol and cholestyramine
Chenodiol's FDA label of December 16, 2025 names cholestyramine in its drug interactions section; the cholestyramine label PlainMeds reads does not name chenodiol. The chenodiol label: “Drugs on CTEXLI Co-administration of bile acid sequestering agents, such as cholestyramine and colestipol, or aluminum-based antacids may decrease absorption of CTEXLI in the intestine and may result in decreased …”
Check it at the source: the chenodiol FDA label on DailyMed (effective December 16, 2025, Mirum Pharmaceuticals Inc.); the cholestyramine FDA label on DailyMed (effective August 20, 2026, AiPing Pharmaceutical, Inc.).
What does the chenodiol label say about cholestyramine?
Chenodiol label, drug interactionsDrugs on CTEXLI Co-administration of bile acid sequestering agents, such as cholestyramine and colestipol, or aluminum-based antacids may decrease absorption of CTEXLI in the intestine and may result in decreased efficacy of CTEXLI.
Source: FDA drug label (CTEXLI), Mirum Pharmaceuticals Inc., effective December 16, 2025 (SPL set 015384e7-4ac5-4782-a309-e40cd1421c5b), via openFDA; the full label on DailyMed
What does the cholestyramine label say about chenodiol?
Cholestyramine's label (effective August 20, 2026) does not name chenodiol in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Cholestyramine), AiPing Pharmaceutical, Inc., effective August 20, 2026 (SPL set 214ea05f-de81-4026-9df9-4ce3820668ee), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Chenodiol | Cholestyramine | |
|---|---|---|
| Labeled for | n/a | High cholesterol |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | n/a | $0.834 per packet Cholestyramine packet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once