What the FDA labels say about taking them together
Chenodiol and colestipol
Chenodiol's FDA label of December 16, 2025 names colestipol in its drug interactions section; the colestipol labels PlainMeds reads (3) do not name chenodiol. The chenodiol label: “Drugs on CTEXLI Co-administration of bile acid sequestering agents, such as cholestyramine and colestipol, or aluminum-based antacids may decrease absorption of CTEXLI in the intestine and may result in decreased …”
Check it at the source: the chenodiol FDA label on DailyMed (effective December 16, 2025, Mirum Pharmaceuticals Inc.); the colestipol FDA label on DailyMed (effective February 19, 2024, Zydus Pharmaceuticals USA Inc.).
What does the chenodiol label say about colestipol?
Chenodiol label, drug interactionsDrugs on CTEXLI Co-administration of bile acid sequestering agents, such as cholestyramine and colestipol, or aluminum-based antacids may decrease absorption of CTEXLI in the intestine and may result in decreased efficacy of CTEXLI.
Source: FDA drug label (CTEXLI), Mirum Pharmaceuticals Inc., effective December 16, 2025 (SPL set 015384e7-4ac5-4782-a309-e40cd1421c5b), via openFDA; the full label on DailyMed
What does the colestipol label say about chenodiol?
Colestipol's label (effective February 19, 2024) and its 2 other brand-application labels do not name chenodiol in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Colestipol hydrochloride), Zydus Pharmaceuticals USA Inc., effective February 19, 2024 (SPL set 71f12e0d-373a-4867-b37c-f24d99c5ce95), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Chenodiol | Colestipol | |
|---|---|---|
| Labeled for | n/a | High cholesterol |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | n/a | $0.658 per tablet 1 g tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once