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What the label lists and what reports show

Streptomycin side effects

Streptomycin's FDA label lists its adverse reactions in its own words. FAERS holds 1,145 reports naming it through July 30, 2026; the reaction reported most often, leaving out the conditions it is used for, product-use terms and outcomes, is pyrexia (97 reports).

  • Generic listed
  • Boxed warning

Check it at the source: the streptomycin FDA label on DailyMed (effective January 21, 2026, XGen Pharmaceuticals DJB, Inc.); the FDA FAERS public dashboard.

What does the label list?

From the label: adverse reactions

The following reactions are common: vestibular ototoxicity (nausea, vomiting, and vertigo); paresthesia of face; rash; fever; urticaria; angioneurotic edema; and eosinophilia. The following reactions are less frequent: cochlear ototoxicity (deafness); exfoliative dermatitis; anaphylaxis; azotemia; leucopenia; thrombocytopenia; pancytopenia; hemolytic anemia; muscular weakness; and amblyopia. Vestibular dysfunction resulting from the parenteral administration of streptomycin is cumulatively related to the total daily dose. When 1.8 to 2 g/day are given, symptoms are likely to develop in the large percentage of patients - especially in the elderly or patients with impaired renal function - within four weeks. …

Source: FDA drug label, XGen Pharmaceuticals DJB, Inc., effective January 21, 2026 (SPL set abd1f64e-4283-4370-aae8-3666316aa36e), via openFDA; the full label on DailyMed

What do FAERS reports show?

1,145 reports list streptomycin among the medicines taken, each a report of something that happened, not proof the medicine caused it; 183 are coded as a death and 375 as a hospital stay. Counts follow how widely a medicine is used and watched, and they are not a measure of how risky it is. Of the 20 reactions below, 5 are named by the same term (in US spelling) in the label's adverse reactions, warnings or patient leaflet; a reaction the label does not name may still be there under another word, and a report does not show that the medicine caused it.

Reports received each year

The 25 most reported reactions

  • Drug Resistance (a use or a product term, not a reaction)147
  • Pyrexia97
  • Drug Ineffective (a use or a product term, not a reaction)62
  • Paradoxical Drug Reaction59
  • Drug Hypersensitivity56
  • Drug Reaction With Eosinophilia And Systemic Symptoms55
  • Tuberculosis (a use or a product term, not a reaction)54
  • Nausea (named in the label)49
  • Drug-Induced Liver Injury47
  • Off Label Use (a use or a product term, not a reaction)41
  • Rash (named in the label)40
  • Vomiting (named in the label)39
  • Diarrhoea (named in the label)37
  • Pathogen Resistance36
  • Hepatitis33
  • Hepatotoxicity32
  • Immune Reconstitution Inflammatory Syndrome Associated Tuberculosis31
  • Treatment Failure (a use or a product term, not a reaction)31
  • Alanine Aminotransferase Increased28
  • Multiple-Drug Resistance28
  • Neuropathy Peripheral28
  • Thrombocytopenia (named in the label)28
  • Immune Reconstitution Inflammatory Syndrome27
  • Jaundice27
  • Optic Neuropathy27

Source: FDA Adverse Event Reporting System (FAERS) via openFDA, reports through July 30, 2026; reactions as MedDRA preferred terms

What next?

Streptomycin: the full record
label, generics, price, shortages, recalls
Side effects hub
the most reported medicines and reactions