LOW-VOLUME · HOSP-HEAVY
perampanel Side Effects
perampanel (also sold as Fycompa) is a LOW-VOLUME FAERS extract #359 of 524 by FAERS report count. Still opens on HOSP-HEAVY: 38.2% mention hospitalization (2,745 reports).
Data updated 2026-05-15
- 7,188
- FAERS reports
Thinner FAERS book - still a temporal association ledger, not proof of cause. Methodology.
perampanel: 38.2% mention hospitalization (2,745 reports). Death stamp DEATH-HEAVY; volume band LOW-VOLUME #359 of 524 by FAERS report count.
Thinner FAERS extract for perampanel (Fycompa) (7,188 reports #359 of 524 by FAERS report count). 38.2% mention hospitalization (2,745 reports). Sparse books still carry named reaction rows when present; not medical advice.
Counts from the openFDA FAERS extract (2012–2025). Stamps WATCHLIST · DEATH-HEAVY · HOSP-HEAVY · SEX-BALANCED.
SEIZURE leads 1,098 of 7,188 reports
Who reports · age peak 18-44 (SEX-BALANCED)
Sex coding · SEX-BALANCED
Age peak 18-44 (2,072 reports)
FAERS filings rising toward 2025
Reactions in Death Reports
Death-mentioned subset is HEAVY here (453 reports, 6.3%). Top co-reported reactions in that subset - voluntary, not causal.
| Reaction | Reports |
|---|---|
| DEATH | 95 |
| SEIZURE | 39 |
| MULTIPLE-DRUG RESISTANCE | 36 |
| SUDDEN UNEXPLAINED DEATH IN EPILEPSY | 32 |
| PNEUMONIA | 29 |
| CARDIAC ARREST | 26 |
| GENERAL PHYSICAL HEALTH DETERIORATION | 26 |
| PNEUMONIA ASPIRATION | 24 |
| STATUS EPILEPTICUS | 24 |
| RESPIRATORY FAILURE | 23 |
| COMPLETED SUICIDE | 22 |
| SEPTIC SHOCK | 19 |
| TOXICITY TO VARIOUS AGENTS | 19 |
| CONDITION AGGRAVATED | 17 |
| SEPSIS | 16 |
| AGGRESSION | 14 |
| EPILEPSY | 14 |
Reactions in Hospitalization Reports
Hospitalization is HEAVY (2,745, 38.2% of the book). Top reactions in those rows:
| Reaction | Reports |
|---|---|
| SEIZURE | 376 |
| SOMNOLENCE | 226 |
| AGGRESSION | 188 |
| STATUS EPILEPTICUS | 186 |
| EPILEPSY | 158 |
| SUICIDE ATTEMPT | 151 |
| INTENTIONAL OVERDOSE | 145 |
| DRUG INTERACTION | 144 |
| DIZZINESS | 138 |
| FALL | 126 |
| FATIGUE | 112 |
| PNEUMONIA | 104 |
| TOXICITY TO VARIOUS AGENTS | 99 |
| HOSPITALISATION | 98 |
| PYREXIA | 98 |
| CONDITION AGGRAVATED | 93 |
| PNEUMONIA ASPIRATION | 84 |
| VOMITING | 81 |
How to read perampanel FAERS figures (WATCHLIST · DEATH-HEAVY · HOSP-HEAVY)
FAERS holds 7,188 voluntary reports linked to perampanel (Fycompa), 2012-2025. Death is listed on 453 (6.3%). Hospitalization appears on 2,745 (38.2%). Top co-reported indication: Product Used For Unknown Indication.
Sparse extract - named reactions and SEX-BALANCED skew still differ by drug; not a complete safety profile.
Read with perampanel
Peers ranked by ABS(total_reports), then an ABS(death_share) pole; guide hop follows DEATH-HEAVY · HOSP-HEAVY stamps.
ABS(total_reports) peer at 7,180 FAERS cases (Δ 8 lighter vs perampanel); DEATH-HEAVY · HOSP-HEAVY · SEX-BALANCED vs this page's WATCHLIST · DEATH-HEAVY · HOSP-HEAVY · SEX-BALANCED.
ABS(total_reports) peer at 7,215 FAERS cases (Δ 27 heavier vs perampanel); DEATH-HEAVY · HOSP-MID · SEX-BALANCED vs this page's WATCHLIST · DEATH-HEAVY · HOSP-HEAVY · SEX-BALANCED.
ABS(total_reports) peer at 7,235 FAERS cases (Δ 47 heavier vs perampanel); DEATH-HEAVY · HOSP-MID · SEX-BALANCED vs this page's WATCHLIST · DEATH-HEAVY · HOSP-HEAVY · SEX-BALANCED.
ABS(total_reports) peer at 7,063 FAERS cases (Δ 125 lighter vs perampanel); DEATH-HEAVY · HOSP-HEAVY · SEX-BALANCED vs this page's WATCHLIST · DEATH-HEAVY · HOSP-HEAVY · SEX-BALANCED.
ABS(death_share) pole at 62.1% death-mentioned reports (Δ 55.8 pp vs perampanel's DEATH-HEAVY): CASELOAD · HOSP-MID.
perampanel stamps DEATH-HEAVY · HOSP-HEAVY; FAERS outcome shares are signal-detection rates, not incidence. Read them next to caseload WATCHLIST and the label guide.