LOW-VOLUME · FEMALE-LED

methimazole Side Effects

methimazole (also sold as Tapazole) is a LOW-VOLUME FAERS extract #352 of 524 by FAERS report count. Still opens on FEMALE-LED: 72% of sex-coded reports are female (4,801 F / 1,869 M).

Data updated 2026-05-15

7,411
FAERS reports

Thinner FAERS book - still a temporal association ledger, not proof of cause. Methodology.

methimazole reporting skew - 72% of sex-coded reports are female (4,801 F / 1,869 M). Volume band LOW-VOLUME #352 of 524 by FAERS report count; caseload WATCHLIST.

Thinner FAERS extract for methimazole (Tapazole) (7,411 reports #352 of 524 by FAERS report count). 72% of sex-coded reports are female (4,801 F / 1,869 M). Sparse books still carry named reaction rows when present; not medical advice.

Counts from the openFDA FAERS extract (2004–2025). Stamps WATCHLIST · DEATH-HEAVY · HOSP-HEAVY · FEMALE-LED.

FATIGUE leads 426 of 7,411 reports

FATIGUE
426
HYPERTHYROIDISM
384
NAUSEA
372
DIARRHOEA
325
HEADACHE
315
PAIN
296
DIZZINESS
292
DYSPNOEA
266
AGRANULOCYTOSIS
243
ASTHENIA
212
ARTHRALGIA
211
RASH
209
ANXIETY
208
CONDITION AGGRAVATED
196
PRURITUS
195
WEIGHT DECREASED
185
PYREXIA
177

FEMALE-LED reporters · age peak 45-64

Female-led reporters (72% of sex-coded rows)

Female 4,801 (72%)
Male 1,869 (28%)
Unknown 7

Age peak 45-64 (1,729 reports)

0-17 276 (5%)
18-44 1,238 (24%)
45-64 1,729 (33%)
65-74 1,024 (20%)
75+ 941 (18%)

FAERS filings rising toward 2025

2004 2025

Reactions in Death Reports

Death-mentioned subset is HEAVY here (615 reports, 8.3%). Top co-reported reactions in that subset - voluntary, not causal.

Reaction Reports
DEATH 172
CARDIAC ARREST 50
MULTIPLE ORGAN DYSFUNCTION SYNDROME 38
PNEUMONIA 37
RESPIRATORY FAILURE 31
AGRANULOCYTOSIS 26
ACUTE KIDNEY INJURY 24
CARDIOGENIC SHOCK 23
SEPTIC SHOCK 23
NEUTROPENIA 22
FATIGUE 21
COMPLETED SUICIDE 19
DYSPNOEA 19
SEPSIS 19
ATRIAL FIBRILLATION 18
DIARRHOEA 18
CARDIO-RESPIRATORY ARREST 17
HYPERTHYROIDISM 17

Reactions in Hospitalization Reports

Hospitalization is HEAVY (2,710, 36.6% of the book). Top reactions in those rows:

Reaction Reports
HYPERTHYROIDISM 206
AGRANULOCYTOSIS 185
DYSPNOEA 138
FATIGUE 133
NAUSEA 123
PYREXIA 115
DIARRHOEA 113
ASTHENIA 107
FALL 100
PNEUMONIA 99
HEADACHE 95
THYROTOXIC CRISIS 95
DIZZINESS 92
PAIN 90
ANAEMIA 89
CARDIAC FAILURE 88
ATRIAL FIBRILLATION 87
WEIGHT DECREASED 83
How to read methimazole FAERS figures (WATCHLIST · DEATH-HEAVY · HOSP-HEAVY)

FAERS holds 7,411 voluntary reports linked to methimazole (Tapazole), 2004-2025. Death is listed on 615 (8.3%). Hospitalization appears on 2,710 (36.6%). Top co-reported indication: Product Used For Unknown Indication.

Sparse extract - named reactions and FEMALE-LED skew still differ by drug; not a complete safety profile.

Read with methimazole

Peers ranked by ABS(total_reports), then an ABS(death_share) pole; guide hop follows DEATH-HEAVY · HOSP-HEAVY stamps.