HIGH-VOLUME · SEX-BALANCED
lamotrigine Side Effects
lamotrigine (also sold as Lamictal) is HIGH-VOLUME in this FAERS book #59 of 524 by FAERS report count. Signature opener: SEX-BALANCED - 68% of sex-coded reports are female (75,506 F / 35,158 M).
Data updated 2026-05-15
- 127,196
- FAERS reports
FAERS voluntary reports, 2002 to 2025. High volume tracks exposure and reporting culture; see methodology for de-dup rules.
lamotrigine reporting skew - 68% of sex-coded reports are female (75,506 F / 35,158 M). Volume band HIGH-VOLUME #59 of 524 by FAERS report count; caseload MEGA-CASE.
High-report extract for lamotrigine (Lamictal): 127,196 FAERS rows (2002-2025). Top named reactions: RASH, SEIZURE, NAUSEA. Outcome stamps DEATH-HEAVY · HOSP-HEAVY · SEX-BALANCED. FAERS is voluntary signal detection, not incidence.
Counts from the openFDA FAERS extract (2002–2025). Stamps MEGA-CASE · DEATH-HEAVY · HOSP-HEAVY · SEX-BALANCED.
RASH leads 8,408 of 127,196 reports
Who reports · age peak 18-44 (SEX-BALANCED)
Sex coding · SEX-BALANCED
Age peak 18-44 (35,619 reports)
FAERS filings rising toward 2025
Reactions in Death Reports
Death-mentioned subset is HEAVY here (10,680 reports, 8.4%). Top co-reported reactions in that subset - voluntary, not causal.
| Reaction | Reports |
|---|---|
| COMPLETED SUICIDE | 3,161 |
| TOXICITY TO VARIOUS AGENTS | 1,790 |
| DEATH | 1,531 |
| GENERAL PHYSICAL HEALTH DETERIORATION | 835 |
| MATERNAL EXPOSURE DURING PREGNANCY | 823 |
| RASH | 770 |
| PEMPHIGUS | 741 |
| TYPE 2 DIABETES MELLITUS | 736 |
| SYSTEMIC LUPUS ERYTHEMATOSUS | 733 |
| CONFUSIONAL STATE | 721 |
| PERICARDITIS | 713 |
| CARDIO-RESPIRATORY ARREST | 711 |
| CARDIAC ARREST | 709 |
| SYNOVITIS | 708 |
| GLOSSODYNIA | 686 |
| HYPERTENSION | 677 |
| PAIN | 674 |
| EPILEPSY | 672 |
Reactions in Hospitalization Reports
Hospitalization is HEAVY (38,667, 30.4% of the book). Top reactions in those rows:
| Reaction | Reports |
|---|---|
| RASH | 3,158 |
| PYREXIA | 2,977 |
| VOMITING | 2,296 |
| NAUSEA | 2,232 |
| SEIZURE | 2,209 |
| DIZZINESS | 2,011 |
| TOXICITY TO VARIOUS AGENTS | 1,979 |
| FATIGUE | 1,960 |
| HEADACHE | 1,934 |
| FALL | 1,910 |
| DEPRESSION | 1,866 |
| CONFUSIONAL STATE | 1,798 |
| DRUG INTERACTION | 1,769 |
| DRUG REACTION WITH EOSINOPHILIA AND SYSTEMIC SYMPTOMS | 1,727 |
| STEVENS-JOHNSON SYNDROME | 1,697 |
| INTENTIONAL OVERDOSE | 1,669 |
| OVERDOSE | 1,623 |
| SOMNOLENCE | 1,612 |
How to read lamotrigine FAERS figures (MEGA-CASE · DEATH-HEAVY · HOSP-HEAVY)
FAERS holds 127,196 voluntary reports linked to lamotrigine (Lamictal), 2002-2025. Death is listed on 10,680 (8.4%). Hospitalization appears on 38,667 (30.4%). Top co-reported indication: Product Used For Unknown Indication.
MEGA-CASE books overweight common drugs and loud reporting cultures; SEX-BALANCED is the page opener, not a per-patient risk.
Read with lamotrigine
Peers ranked by ABS(total_reports), then an ABS(death_share) pole; guide hop follows DEATH-HEAVY · HOSP-HEAVY stamps.
ABS(total_reports) peer at 127,698 FAERS cases (Δ 502 heavier vs lamotrigine); DEATH-HEAVY · HOSP-HEAVY · SEX-BALANCED vs this page's MEGA-CASE · DEATH-HEAVY · HOSP-HEAVY · SEX-BALANCED.
ABS(total_reports) peer at 128,099 FAERS cases (Δ 903 heavier vs lamotrigine); DEATH-HEAVY · HOSP-HEAVY · FEMALE-LED vs this page's MEGA-CASE · DEATH-HEAVY · HOSP-HEAVY · SEX-BALANCED.
ABS(total_reports) peer at 124,873 FAERS cases (Δ 2,323 lighter vs lamotrigine); DEATH-HEAVY · HOSP-HEAVY · SEX-BALANCED vs this page's MEGA-CASE · DEATH-HEAVY · HOSP-HEAVY · SEX-BALANCED.
ABS(total_reports) peer at 129,958 FAERS cases (Δ 2,762 heavier vs lamotrigine); DEATH-HEAVY · HOSP-HEAVY · SEX-BALANCED vs this page's MEGA-CASE · DEATH-HEAVY · HOSP-HEAVY · SEX-BALANCED.
ABS(death_share) pole at 62.1% death-mentioned reports (Δ 53.7 pp vs lamotrigine's DEATH-HEAVY): CASELOAD · HOSP-MID.
lamotrigine stamps DEATH-HEAVY · HOSP-HEAVY; FAERS outcome shares are signal-detection rates, not incidence. Read them next to caseload MEGA-CASE and the label guide.