LOW-VOLUME · SEX-BALANCED
imipramine Side Effects
imipramine (also sold as Tofranil) is a LOW-VOLUME FAERS extract #506 of 524 by FAERS report count. Still opens on SEX-BALANCED: 69% of sex-coded reports are female (346 F / 159 M).
Data updated 2026-05-15
- 537
- FAERS reports
Thinner FAERS book - still a temporal association ledger, not proof of cause. Methodology.
imipramine reporting skew - 69% of sex-coded reports are female (346 F / 159 M). Volume band LOW-VOLUME #506 of 524 by FAERS report count; caseload SIGNAL.
Thinner FAERS extract for imipramine (Tofranil) (537 reports #506 of 524 by FAERS report count). 69% of sex-coded reports are female (346 F / 159 M). Sparse books still carry named reaction rows when present; not medical advice.
Counts from the openFDA FAERS extract (2004–2025). Stamps SIGNAL · DEATH-HEAVY · HOSP-HEAVY · SEX-BALANCED.
DIZZINESS leads 35 of 537 reports
Who reports · age peak 45-64 (SEX-BALANCED)
Sex coding · SEX-BALANCED
Age peak 45-64 (132 reports)
FAERS filings rising toward 2025
Reactions in Death Reports
Death-mentioned subset is HEAVY here (30 reports, 5.6%). Top co-reported reactions in that subset - voluntary, not causal.
| Reaction | Reports |
|---|---|
| DEATH | 8 |
| COMPLETED SUICIDE | 7 |
| TOXICITY TO VARIOUS AGENTS | 6 |
| DEPRESSED LEVEL OF CONSCIOUSNESS | 4 |
| OVERDOSE | 4 |
| ASPHYXIA | 3 |
| PNEUMONIA | 3 |
| RESPIRATORY DISORDER | 3 |
| SOMNOLENCE | 3 |
| ARTHRALGIA | 2 |
| ARTHROPATHY | 2 |
| ASPIRATION | 2 |
| B-CELL SMALL LYMPHOCYTIC LYMPHOMA | 2 |
| CARDIAC ARREST | 2 |
| CERUMEN IMPACTION | 2 |
| CERVICAL RADICULOPATHY | 2 |
| CHRONIC KIDNEY DISEASE | 2 |
| CHRONIC LYMPHOCYTIC LEUKAEMIA | 2 |
| CYANOSIS | 2 |
| DIFFUSE LARGE B-CELL LYMPHOMA | 2 |
Reactions in Hospitalization Reports
Hospitalization is HEAVY (198, 36.9% of the book). Top reactions in those rows:
| Reaction | Reports |
|---|---|
| HALLUCINATION, AUDITORY | 25 |
| PSYCHOTIC DISORDER | 25 |
| PARANOIA | 24 |
| COLITIS | 18 |
| COLITIS ULCERATIVE | 17 |
| DECREASED ACTIVITY | 16 |
| FREQUENT BOWEL MOVEMENTS | 16 |
| RECTAL HAEMORRHAGE | 16 |
| DIZZINESS | 15 |
| DEPRESSION | 14 |
| FATIGUE | 14 |
| PNEUMONIA | 14 |
| ARTHRALGIA | 13 |
| DYSPNOEA | 13 |
| HYPERTENSION | 13 |
| NAUSEA | 13 |
| URINARY TRACT INFECTION | 13 |
| ANXIETY | 12 |
| CHEST PAIN | 12 |
| PYREXIA | 12 |
How to read imipramine FAERS figures (SIGNAL · DEATH-HEAVY · HOSP-HEAVY)
FAERS holds 537 voluntary reports linked to imipramine (Tofranil), 2004-2025. Death is listed on 30 (5.6%). Hospitalization appears on 198 (36.9%). Top co-reported indication: Product Used For Unknown Indication.
Sparse extract - named reactions and SEX-BALANCED skew still differ by drug; not a complete safety profile.
Read with imipramine
Peers ranked by ABS(total_reports), then an ABS(death_share) pole; guide hop follows DEATH-HEAVY · HOSP-HEAVY stamps.
ABS(total_reports) peer at 541 FAERS cases (Δ 4 heavier vs imipramine); DEATH-HEAVY · HOSP-HEAVY · SEX-BALANCED vs this page's SIGNAL · DEATH-HEAVY · HOSP-HEAVY · SEX-BALANCED.
ABS(total_reports) peer at 531 FAERS cases (Δ 6 lighter vs imipramine); DEATH-HEAVY · HOSP-MID · SEX-BALANCED vs this page's SIGNAL · DEATH-HEAVY · HOSP-HEAVY · SEX-BALANCED.
ABS(total_reports) peer at 520 FAERS cases (Δ 17 lighter vs imipramine); DEATH-HEAVY · HOSP-HEAVY · SEX-BALANCED vs this page's SIGNAL · DEATH-HEAVY · HOSP-HEAVY · SEX-BALANCED.
ABS(total_reports) peer at 580 FAERS cases (Δ 43 heavier vs imipramine); DEATH-HEAVY · HOSP-HEAVY · SEX-BALANCED vs this page's SIGNAL · DEATH-HEAVY · HOSP-HEAVY · SEX-BALANCED.
ABS(death_share) pole at 62.1% death-mentioned reports (Δ 56.5 pp vs imipramine's DEATH-HEAVY): CASELOAD · HOSP-MID.
imipramine stamps DEATH-HEAVY · HOSP-HEAVY; FAERS outcome shares are signal-detection rates, not incidence. Read them next to caseload SIGNAL and the label guide.