Prescription medicine
Estrogens conjugated and medroxyprogesterone Brand names: Prempro; first approved as Prempro (Premarin;Cycrin)
Estrogens conjugated and medroxyprogesterone (Prempro) is a prescription medicine with an FDA approval on record since 1994. No generic is listed; pharmacies paid $8.68 per Prempro 0.3 mg-1.5 mg tablet in the October 7, 2026 NADAC survey.
- No generic listed
Check it at the source: estrogens conjugated and medroxyprogesterone labels on DailyMed; the NDA 20303 record on Drugs@FDA; every estrogens conjugated and medroxyprogesterone label on DailyMed.
Highlights of the record
no current FDA label; NDC Directory, Drugs@FDA and Orange Book, October 8, 2026; NADAC October 7, 2026
Used for
The label in openFDA carries no indications section.
Forms and strengths
- 0.3 mg / 1.5 mg
- 0.45 mg / 1.5 mg
- 0.625 mg / 5 mg
- 0.625 mg / 2.5 mg
Sugar-coated tablet.
On the market
- Earliest approval on file
- December 30, 1994 Prempro (Premarin;Cycrin), Wyeth Pharms Inc; Drugs@FDA’s file, where older or withdrawn approvals can be missing
- Generic approvals
- No generic approved
- Labelers listed (NDC)
- 1 of which 0 under generic applications, 1 under brand applications, repackagers included
Supply and safety
- Pharmacy cost (NADAC)
- $8.68 per tablet Prempro 0.3 mg-1.5 mg tablet
- Shortage (FDA)
- No current entry
- Recalls by its makers (FDA)
- No recall recorded
- FAERS reports
- 23,464 through July 30, 2026
Is there a generic for estrogens conjugated and medroxyprogesterone (Prempro)?
No generic estrogens conjugated and medroxyprogesterone is approved (Drugs@FDA, October 8, 2026).
- 1994 earliest approval on file
Source: Drugs@FDA, FDA NDC Directory and the Orange Book (openFDA bulk files, October 8, 2026)
What do pharmacies pay for estrogens conjugated and medroxyprogesterone (Prempro)?
In CMS's NADAC survey of October 7, 2026, pharmacies paid $8.68 per Prempro 0.3 mg-1.5 mg tablet, up 2% from $8.47 on October 8, 2025. The chart's scale runs from the lowest to the highest price shown, not from zero. NADAC is what retail pharmacies paid their wholesalers, per unit, in CMS's monthly survey; what a patient pays depends on insurance and the pharmacy.
- Prempro 0.625-5 mg tablet (brand)
| Strength and form | Brand or generic | Pharmacy cost | 30 tablets, or one pen or vial | 12-month change |
|---|---|---|---|---|
| Prempro 0.3 mg-1.5 mg tablet | Brand | $8.68 per tablet | $260.32 | +2% |
| Prempro 0.45-1.5 mg tablet | Brand | $8.68 per tablet | $260.51 | +2% |
| Prempro 0.625-2.5 mg tablet | Brand | $8.68 per tablet | $260.35 | +3% |
| Prempro 0.625-5 mg tablet | Brand | $8.67 per tablet | $259.99 | +2% |
Source: CMS National Average Drug Acquisition Cost (NADAC) survey, October 7, 2026: what retail pharmacies paid per unit; not a counter price
What do FAERS reports show for estrogens conjugated and medroxyprogesterone?
The FDA Adverse Event Reporting System holds 23,464 reports that list estrogens conjugated and medroxyprogesterone among the medicines taken, through July 30, 2026, each a report of something that happened, not proof the medicine caused it; 647 are coded as a death and 2,758 as a hospital stay. Counts follow how widely a medicine is used and watched, and they are not a measure of how risky it is.
Reports received each year
The most reported reactions
Source: FDA Adverse Event Reporting System (FAERS) via openFDA, reports through July 30, 2026
What next?
- Other estrogens
- the pharmacologic class, with prices and generics
- Estrogens conjugated and medroxyprogesterone side effects
- the label's list beside FAERS reports
- Check an interaction
- what two or more labels say about each other