FDA pharmacologic class
Estrogens
2 medicines are in FDA's class of estrogens (estrogens): estradiol (Climara) and estrogens conjugated (Premarin); 13 combination products also contain one. 8 of the 15 are listed from generic labelers (FDA NDC Directory, October 8, 2026). The lowest pharmacy cost is estradiol 1 mg tablet at $0.0635 per tablet (NADAC).
Which medicines are estrogens?
| Medicine | Brand names | Generic labelers (all forms) | Pharmacy cost | Boxed warning | Shortage | Recalls since 2012 |
|---|---|---|---|---|---|---|
| Estradiol | Climara, Divigel, Minivelle | 40 labelers | $0.0635 per tablet 1 mg tablet | Yes | No current entry | 60 |
| Ethinyl estradiol and norethindrone | Femlyv, Nortrel, Alyacen | 18 labelers | $0.181 per tablet 21 1-20 tablet | Yes | No current entry | 8 |
| Ethinyl estradiol and levonorgestrel | Twirla, Tyblume, Balcoltra | 19 labelers | $0.154 per tablet 28 tablet | Yes | No current entry | 9 |
| Ethinyl estradiol and ferrous fumarate and norethindrone | Taytulla, Junel, Microgestin | 22 labelers | $0.142 per tablet 1.5-30 tablet | Yes | No current entry | 3 |
| Estradiol and norethindrone | Lopreeza, Combipatch, Activella | 7 labelers | $0.802 per tablet 0.5-0.1 mg tablet | Yes | No current entry | 4 |
| Estrogens conjugated | Premarin | 1 labeler | $5.47 per tablet 0.625 mg tablet | Yes | No current entry | 0 |
| Ethinyl estradiol and etonogestrel | Nuvaring, Eluryng, Enilloring | 5 labelers | $46.35 per ring Etonogestrel-ee vaginal ring | Yes | No current entry | 0 |
| Ethinyl estradiol and norelgestromin | Gwyn, Zafemy, Xulane | 8 labelers | $37.16 per patch 150-35 mcg/day patch | Yes | No current entry | 0 |
| Estrogens conjugated and medroxyprogesterone | Prempro | none listed | $8.68 per tablet 0.3 mg-1.5 mg tablet | No | No current entry | 0 |
| Bazedoxifene and estrogens conjugated | Duavee | none listed | $6.48 per tablet 0.45-20 mg tablet | Yes | No current entry | 0 |
| Drospirenone and estradiol | Angeliq | none listed | $6.37 per tablet 0.25 mg-0.5 mg tablet | Yes | No current entry | 0 |
| Ethinyl estradiol and segesterone | Annovera | none listed | $2,315.29 per ring Annovera vaginal ring | Yes | No current entry | 0 |
| Conjugated estrogens and medroxyprogesterone | Premphase | none listed | $8.68 per tablet 0.625-5 mg tablet | No | No current entry | 0 |
| Estradiol and levonorgestrel | Climara | none listed | $59.64 per patch Climara pro patch | Yes | No current entry | 0 |
| Estradiol and norethindrone and relugolix | Myfembree | none listed | $45.25 per tablet 40 mg-1 mg-0.5 mg tablet | Yes | No current entry | 0 |
Source: FDA Established Pharmacologic Class (NDC Directory, openFDA); CMS NADAC of October 7, 2026; FDA shortages and recalls (FDA files October 8, 2026)
What do pharmacies pay?
Each medicine's most widely listed form, per unit, in the NADAC survey: what pharmacies paid, not what a patient pays; strengths differ, so compare like with like.
Source: CMS National Average Drug Acquisition Cost (NADAC) survey, October 7, 2026: what retail pharmacies paid per unit; not a counter price