Drug side effects
diazoxide Side Effects
The reactions most often reported to the FDA for diazoxide (also sold as Proglycem), with demographics, serious outcomes, and reporting trends.
Data updated 2026-05-15
- 705
- FAERS reports
Data from the FDA Adverse Event Reporting System (FAERS), 2004 to 2025. A FAERS report records a temporal association, not proof of cause. See our methodology for how figures are compiled and de-duplicated.
The most commonly reported side effects of diazoxide come from 705 reports to the FDA, broken down here by frequency, patient demographics, and serious outcomes.
This page analyzes 705 reports to the FDA Adverse Event Reporting System (FAERS) for diazoxide (Proglycem): the reactions reported most often, who reported them, serious outcomes such as hospitalization, and year-over-year trends. A FAERS report does not prove the drug caused the effect, and report volume tracks how widely a drug is used, not how likely an effect is for any one person. Educational information, not medical advice.
Total Reports
705
Reports Mentioning Death
95
13.5% of reports — not proof the medicine caused the death
Hospitalizations
298
42.3% of reports
Top Indication
Hypoglycaemia
Most Reported Adverse Reactions
Who Reports Side Effects
Gender Distribution
Age Distribution
Reporting Trend by Year
Reactions in Death Reports
Top reactions reported in 95 reports where death was an outcome. These are voluntarily reported and do not establish causation.
| Reaction | Reports |
|---|---|
| DEATH | 22 |
| HYPOGLYCAEMIA | 15 |
| CARDIAC FAILURE | 10 |
| MALIGNANT NEOPLASM PROGRESSION | 10 |
| INSULINOMA | 9 |
| SEPSIS | 8 |
| HYPERGLYCAEMIA | 5 |
| NECROTISING COLITIS | 5 |
| RENAL FAILURE | 5 |
| HYPOGLYCAEMIC SEIZURE | 4 |
| HYPOTENSION | 4 |
| HYPOXIA | 4 |
| MULTI-ORGAN FAILURE | 4 |
| NEUTROPENIA | 4 |
| ASTHENIA | 3 |
| CARDIO-RESPIRATORY ARREST | 3 |
| CONDITION AGGRAVATED | 3 |
| DISEASE PROGRESSION | 3 |
Reactions in Hospitalization Reports
Top reactions in 298 reports where hospitalization was an outcome.
| Reaction | Reports |
|---|---|
| HYPOGLYCAEMIA | 45 |
| HYPERGLYCAEMIA | 21 |
| OEDEMA PERIPHERAL | 21 |
| DRUG INEFFECTIVE FOR UNAPPROVED INDICATION | 18 |
| PULMONARY HYPERTENSION | 15 |
| DRUG INTERACTION | 14 |
| CARDIAC FAILURE CONGESTIVE | 13 |
| HYPERGLYCAEMIC HYPEROSMOLAR NONKETOTIC SYNDROME | 13 |
| MALIGNANT NEOPLASM PROGRESSION | 12 |
| OEDEMA | 12 |
| PNEUMONIA | 12 |
| PYREXIA | 12 |
| THROMBOCYTOPENIA | 12 |
| NAUSEA | 11 |
| WEIGHT DECREASED | 11 |
| WEIGHT INCREASED | 11 |
| FALL | 10 |
| INSULINOMA | 10 |
Nearby, Related Medications
What the FAERS Data Reveals About diazoxide Side Effects
The FDA Adverse Event Reporting System (FAERS) contains 705 voluntary reports linked to diazoxide and its brand equivalents (Proglycem), spanning 2004 through 2025. Of those, 95 (13.5%) listed death as an outcome and 298 (42.3%) involved hospitalization. The most common indication reported alongside adverse events was Hypoglycaemia.
Demographic breakdowns help contextualize who is being exposed to the drug. Of reports with known sex, 52% were female and 47% male; age distribution skews toward 0-17, with 165 reports in that bracket. The single most reported reaction is hypoglycaemia with 97 submissions, followed by hyperglycaemia and drug ineffective for unapproved indication.
How to read these numbers
FAERS is a signal-detection tool, not a scorecard. Reports are voluntary, and a single case may list multiple suspect drugs, so numbers above should not be read as incidence rates or per-patient risk. Widely prescribed drugs naturally accumulate more reports than niche therapies even when individual risk is low. These aggregates are useful for spotting patterns that merit further pharmacovigilance, not for choosing between medications. This page is for educational reference only and is not medical advice, speak with a licensed clinician about any side-effect concerns.
Drugs With a Similar FAERS Report Volume
Other medications with a total FDA adverse-event report count closest to diazoxide's 705.
Read our methodology - how this data is sourced, computed, and verified.