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Prescription medicine

Conjugated estrogens and medroxyprogesterone Brand names: Premphase

Conjugated estrogens and medroxyprogesterone (Premphase) is a prescription medicine. No generic is listed; pharmacies paid $8.68 per Premphase 0.625-5 mg tablet in the October 7, 2026 NADAC survey.

  • No generic listed

Check it at the source: conjugated estrogens and medroxyprogesterone labels on DailyMed; every conjugated estrogens and medroxyprogesterone label on DailyMed.

Highlights of the record

no current FDA label; NDC Directory, Drugs@FDA and Orange Book, October 8, 2026; NADAC October 7, 2026

Used for

The label in openFDA carries no indications section.

Forms and strengths

Kit.

On the market

Generic approvals
No generic approved
Labelers listed (NDC)
1 of which 0 under generic applications, 1 under brand applications, repackagers included

Supply and safety

Pharmacy cost (NADAC)
$8.68 per tablet Premphase 0.625-5 mg tablet
Shortage (FDA)
No current entry
Recalls by its makers (FDA)
No recall recorded
FAERS reports
23,464 through July 30, 2026

Is there a generic for conjugated estrogens and medroxyprogesterone (Premphase)?

No generic conjugated estrogens and medroxyprogesterone is approved (Drugs@FDA, October 8, 2026).

Source: Drugs@FDA, FDA NDC Directory and the Orange Book (openFDA bulk files, October 8, 2026)

What do pharmacies pay for conjugated estrogens and medroxyprogesterone (Premphase)?

In CMS's NADAC survey of October 7, 2026, pharmacies paid $8.68 per Premphase 0.625-5 mg tablet, up 2% from $8.48 on October 8, 2025. The chart's scale runs from the lowest to the highest price shown, not from zero. NADAC is what retail pharmacies paid their wholesalers, per unit, in CMS's monthly survey; what a patient pays depends on insurance and the pharmacy.

  • Premphase 0.625-5 mg tablet (brand)
$8.68
$8.28
January 2024October 2026
NADAC per unit, October 7, 2026
Strength and formBrand or genericPharmacy cost30 tablets, or one pen or vial12-month change
Premphase 0.625-5 mg tabletBrand$8.68 per tablet$260.44+2%

Source: CMS National Average Drug Acquisition Cost (NADAC) survey, October 7, 2026: what retail pharmacies paid per unit; not a counter price

What do FAERS reports show for conjugated estrogens and medroxyprogesterone?

The FDA Adverse Event Reporting System holds 23,464 reports that list conjugated estrogens and medroxyprogesterone among the medicines taken, through July 30, 2026, each a report of something that happened, not proof the medicine caused it; 647 are coded as a death and 2,758 as a hospital stay. Counts follow how widely a medicine is used and watched, and they are not a measure of how risky it is.

Reports received each year

The most reported reactions

  • Breast Cancer7,888
  • Breast Cancer Female5,791
  • Breast Cancer Metastatic1,505
  • Drug Ineffective (a use or a product term, not a reaction)733
  • Cerebrovascular Accident501
  • Depression478
  • Headache422
  • Anxiety418

Source: FDA Adverse Event Reporting System (FAERS) via openFDA, reports through July 30, 2026

What next?

Other estrogens
the pharmacologic class, with prices and generics
Check an interaction
what two or more labels say about each other