HIGH-VOLUME · HOSP-HEAVY
clozapine Side Effects
clozapine (also sold as Clozaril) is HIGH-VOLUME in this FAERS book #61 of 524 by FAERS report count. Signature opener: HOSP-HEAVY - 43.7% mention hospitalization (53,005 reports).
Data updated 2026-05-15
- 121,298
- FAERS reports
FAERS voluntary reports, 2001 to 2025. High volume tracks exposure and reporting culture; see methodology for de-dup rules.
clozapine: 43.7% mention hospitalization (53,005 reports). Death stamp DEATH-HEAVY; volume band HIGH-VOLUME #61 of 524 by FAERS report count.
High-report extract for clozapine (Clozaril): 121,298 FAERS rows (2001-2025). Top named reactions: NEUTROPENIA, HOSPITALISATION, DEATH. Outcome stamps DEATH-HEAVY · HOSP-HEAVY · SEX-BALANCED. FAERS is voluntary signal detection, not incidence.
Counts from the openFDA FAERS extract (2001–2025). Stamps MEGA-CASE · DEATH-HEAVY · HOSP-HEAVY · SEX-BALANCED.
NEUTROPENIA leads 18,655 of 121,298 reports
Who reports · age peak 18-44 (SEX-BALANCED)
Sex coding · SEX-BALANCED
Age peak 18-44 (30,098 reports)
FAERS filings rising toward 2025
Reactions in Death Reports
Death-mentioned subset is HEAVY here (21,448 reports, 17.7%). Top co-reported reactions in that subset - voluntary, not causal.
| Reaction | Reports |
|---|---|
| DEATH | 11,395 |
| PNEUMONIA | 1,078 |
| COMPLETED SUICIDE | 743 |
| MYOCARDIAL INFARCTION | 736 |
| CARDIAC ARREST | 689 |
| NEUTROPHIL COUNT INCREASED | 599 |
| WHITE BLOOD CELL COUNT INCREASED | 508 |
| TOXICITY TO VARIOUS AGENTS | 499 |
| MALAISE | 478 |
| LUNG NEOPLASM MALIGNANT | 458 |
| FALL | 428 |
| NEOPLASM MALIGNANT | 426 |
| OVERDOSE | 410 |
| PNEUMONIA ASPIRATION | 391 |
| GENERAL PHYSICAL HEALTH DETERIORATION | 390 |
| SEPSIS | 348 |
| NEUTROPHILIA | 346 |
| CHRONIC OBSTRUCTIVE PULMONARY DISEASE | 338 |
| DYSPNOEA | 330 |
Reactions in Hospitalization Reports
Hospitalization is HEAVY (53,005, 43.7% of the book). Top reactions in those rows:
| Reaction | Reports |
|---|---|
| HOSPITALISATION | 12,089 |
| SCHIZOPHRENIA | 3,328 |
| MALAISE | 2,582 |
| TREATMENT NONCOMPLIANCE | 2,492 |
| PNEUMONIA | 2,319 |
| NEUTROPENIA | 2,292 |
| PSYCHOTIC DISORDER | 2,213 |
| NEUTROPHIL COUNT INCREASED | 2,178 |
| WHITE BLOOD CELL COUNT INCREASED | 2,169 |
| WHITE BLOOD CELL COUNT DECREASED | 1,978 |
| FALL | 1,827 |
| MENTAL IMPAIRMENT | 1,676 |
| PYREXIA | 1,674 |
| TACHYCARDIA | 1,507 |
| DRUG INTERACTION | 1,481 |
| CONFUSIONAL STATE | 1,442 |
| NEUTROPHIL COUNT DECREASED | 1,363 |
| CONSTIPATION | 1,336 |
How to read clozapine FAERS figures (MEGA-CASE · DEATH-HEAVY · HOSP-HEAVY)
FAERS holds 121,298 voluntary reports linked to clozapine (Clozaril), 2001-2025. Death is listed on 21,448 (17.7%). Hospitalization appears on 53,005 (43.7%). Top co-reported indication: Product Used For Unknown Indication.
MEGA-CASE books overweight common drugs and loud reporting cultures; HOSP-HEAVY is the page opener, not a per-patient risk.
Read with clozapine
Peers ranked by ABS(total_reports), then an ABS(death_share) pole; guide hop follows DEATH-HEAVY · HOSP-HEAVY stamps.
ABS(total_reports) peer at 120,921 FAERS cases (Δ 377 lighter vs clozapine); DEATH-RARE · HOSP-LIGHT · FEMALE-LED vs this page's MEGA-CASE · DEATH-HEAVY · HOSP-HEAVY · SEX-BALANCED.
ABS(total_reports) peer at 119,507 FAERS cases (Δ 1,791 lighter vs clozapine); DEATH-HEAVY · HOSP-HEAVY · SEX-BALANCED vs this page's MEGA-CASE · DEATH-HEAVY · HOSP-HEAVY · SEX-BALANCED.
ABS(total_reports) peer at 118,365 FAERS cases (Δ 2,933 lighter vs clozapine); DEATH-HEAVY · HOSP-MID · SEX-BALANCED vs this page's MEGA-CASE · DEATH-HEAVY · HOSP-HEAVY · SEX-BALANCED.
ABS(total_reports) peer at 117,869 FAERS cases (Δ 3,429 lighter vs clozapine); DEATH-HEAVY · HOSP-HEAVY · SEX-BALANCED vs this page's MEGA-CASE · DEATH-HEAVY · HOSP-HEAVY · SEX-BALANCED.
ABS(death_share) pole at 62.1% death-mentioned reports (Δ 44.4 pp vs clozapine's DEATH-HEAVY): CASELOAD · HOSP-MID.
clozapine stamps DEATH-HEAVY · HOSP-HEAVY; FAERS outcome shares are signal-detection rates, not incidence. Read them next to caseload MEGA-CASE and the label guide.