vilazodone vs voriconazole
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Side-by-side comparison of vilazodone and voriconazole. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
Strong CYP3A4 Inhibitors (e.g., itraconazole, clarithromycin, voriconazole) The concomitant use of vilazodone hydrochloride tablets and strong CYP3A4 inhibitors increased the exposure of vilazodone compared to the use of vilazodone hydrochloride tablets alone [see Clinical Pharmacology (12.3)].
Viibryd
Vfend
Vilazodone (Viibryd) is a medicine used to treat depression in adults. It helps to improve your mood.
Voriconazole (Vfend) is an antifungal medicine. It is used to treat serious fungal infections in adults and children 2 years and older.
Vilazodone is used to treat major depressive disorder (MDD) in adults. MDD can cause you to feel sad, lose interest in activities, and have trouble with daily life. This medicine can help improve these symptoms.
This medicine treats several types of fungal infections. It is used for invasive aspergillosis, a lung infection. It also treats candidemia (a blood infection) and other Candida infections in the skin, abdomen, kidney, bladder, and wounds. Voriconazole can also treat esophageal candidiasis (a throat infection) and serious infections caused by Scedosporium and Fusarium fungi.
Vilazodone works by affecting certain chemicals in the brain. It increases the amount of serotonin available. Serotonin helps to regulate mood and emotions.
Voriconazole belongs to a class of drugs called azole antifungals. It works by stopping the growth of fungi. It does this by interfering with the production of the fungal cell membrane.
- • Diarrhea
- • Nausea
- • Vomiting
- • Trouble sleeping (insomnia)
- • Visual disturbances
- • Fever
- • Nausea
- • Rash
- • Vomiting
- Diarrhoea 808
- Nausea 808
- Anxiety 662
- Insomnia 634
- Headache 565
- Drug Interaction 2,315
- Death 1,460
- Pyrexia 1,411
- Pneumonia 1,321
- Condition Aggravated 1,093
Antidepressants may increase the risk of suicidal thoughts and behaviors in young adults. Your doctor should closely monitor you for worsening depression or suicidal thoughts, especially when you first start taking this medicine or when your dose is changed. Vilazodone is not approved for use in children.
Voriconazole can cause serious liver problems. Your doctor will check your liver function with blood tests before and during treatment. This medicine can also cause heart rhythm problems. Make sure your potassium, magnesium, and calcium levels are normal before starting. Voriconazole can also cause severe skin reactions and make you sensitive to sunlight. Avoid sunlight and wear protective clothing. This medicine can harm an unborn baby, so women who can get pregnant should use effective birth control.
Tell your doctor if you are pregnant or plan to become pregnant. Taking vilazodone late in pregnancy may cause problems for the newborn. There is a pregnancy registry to monitor outcomes in women exposed to antidepressants during pregnancy. You can call 1-844-405-6185 to register.
Voriconazole can cause harm to an unborn baby. If you are pregnant or could become pregnant, talk to your doctor. It is not known if voriconazole passes into breast milk. Talk to your doctor about the risks and benefits of breastfeeding while taking this medicine.
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How to Read This vilazodone vs voriconazole Comparison
vilazodone is classified in the SSRI / 5-HT1A Partial Agonist drug class, while voriconazole sits within the Azole Antifungal class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, vilazodone has 3,477 submissions while voriconazole has 7,600. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to voriconazole slows down how fast your body breaks down vilazodone. this can cause the amount of vilazodone in your blood to rise to higher levels.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for vilazodone or voriconazole.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.