omeprazole vs voriconazole
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Side-by-side comparison of omeprazole and voriconazole. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
Omeprazole (CYP2C19/3A4 Inhibition) Significantly Increased When initiating therapy with VFEND in patients already receiving omeprazole doses of 40 mg or greater, reduce the omeprazole dose by one-half.
Prilosec
Vfend
Omeprazole (Prilosec) is a medicine that reduces the amount of acid in your stomach. It belongs to a class of drugs called proton pump inhibitors (PPIs).
Voriconazole (Vfend) is an antifungal medicine. It is used to treat serious fungal infections in adults and children 2 years and older.
This medicine treats frequent heartburn, which is heartburn that occurs 2 or more days a week. It is not meant to give you immediate relief from heartburn. It may take 1 to 4 days for the medicine to fully work.
This medicine treats several types of fungal infections. It is used for invasive aspergillosis, a lung infection. It also treats candidemia (a blood infection) and other Candida infections in the skin, abdomen, kidney, bladder, and wounds. Voriconazole can also treat esophageal candidiasis (a throat infection) and serious infections caused by Scedosporium and Fusarium fungi.
Omeprazole works by blocking the production of acid in your stomach. It does this by targeting the cells that make stomach acid. This helps to reduce heartburn symptoms.
Voriconazole belongs to a class of drugs called azole antifungals. It works by stopping the growth of fungi. It does this by interfering with the production of the fungal cell membrane.
- • Headache
- • Visual disturbances
- • Fever
- • Nausea
- • Rash
- • Vomiting
- Fatigue 19,901
- Nausea 19,842
- Diarrhoea 19,627
- Dyspnoea 16,336
- Headache 14,629
- Drug Interaction 2,315
- Death 1,460
- Pyrexia 1,411
- Pneumonia 1,321
- Condition Aggravated 1,093
Children under 18 should ask a doctor before use. Heartburn in children may be a sign of a serious condition.
Voriconazole can cause serious liver problems. Your doctor will check your liver function with blood tests before and during treatment. This medicine can also cause heart rhythm problems. Make sure your potassium, magnesium, and calcium levels are normal before starting. Voriconazole can also cause severe skin reactions and make you sensitive to sunlight. Avoid sunlight and wear protective clothing. This medicine can harm an unborn baby, so women who can get pregnant should use effective birth control.
Talk to your doctor if you are pregnant or breastfeeding before taking this medicine. It is important to weigh the benefits and risks with your doctor.
Voriconazole can cause harm to an unborn baby. If you are pregnant or could become pregnant, talk to your doctor. It is not known if voriconazole passes into breast milk. Talk to your doctor about the risks and benefits of breastfeeding while taking this medicine.
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How to Read This omeprazole vs voriconazole Comparison
omeprazole is classified in the Proton Pump Inhibitor (PPI) drug class, while voriconazole sits within the Azole Antifungal class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are split between OTC and prescription status, which affects access and supervision.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, omeprazole has 90,335 submissions while voriconazole has 7,600. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to voriconazole stops your body from breaking down omeprazole normally. this leads to much higher levels of omeprazole in your system.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for omeprazole or voriconazole.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.