nicardipine vs warfarin
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Side-by-side comparison of nicardipine and warfarin. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
When therapeutic concentrations of furosemide, propranolol, dipyridamole, warfarin, quinidine or naproxen were added to human plasma (in vitro), the plasma protein binding of nicardipine hydrochloride capsules were not altered.
Cardene
Coumadin, Jantoven
Nicardipine is a drug that helps to lower blood pressure and treat chest pain. It belongs to a class of drugs called calcium channel blockers.
Warfarin is a medicine that helps prevent blood clots. It is used to treat and prevent dangerous clots from forming in your body.
Nicardipine treats chronic stable angina, which is chest pain that happens when you exert yourself. It can be used alone or with beta-blockers to manage this condition. Nicardipine also treats high blood pressure, and it can be used alone or with other blood pressure medications.
Warfarin is used to prevent and treat blood clots in your veins and lungs. It can also prevent clots if you have atrial fibrillation (irregular heartbeat) or a replacement heart valve. After a heart attack, it can lower the risk of death, another heart attack, or a stroke.
Nicardipine works by blocking calcium from entering certain cells in your heart and blood vessels. This helps to relax and widen your blood vessels, which lowers blood pressure. It also reduces the workload on your heart, which can help to relieve chest pain.
Warfarin works by blocking your body's use of vitamin K. Vitamin K is needed to make blood clotting factors. By blocking vitamin K, warfarin makes your blood less likely to clot.
- • Swelling in your feet or ankles
- • Dizziness
- • Headache
- • Weakness
- • Flushing (redness of the skin)
- • Bleeding from any tissue or organ
- Acute Kidney Injury 226
- Premature Baby 205
- Foetal Exposure During Pregnancy 194
- Maternal Exposure During Pregnancy 180
- Drug Interaction 167
- International Normalised Ratio Increased 10,276
- Dyspnoea 8,408
- Drug Interaction 6,288
- Fatigue 6,143
- Nausea 5,921
If you have advanced aortic stenosis, you should not take this medication. Lowering blood pressure in this case could worsen oxygen balance to the heart. Use caution if you have congestive heart failure.
Warfarin can cause major or fatal bleeding. You must have your blood tested regularly (INR) while taking warfarin. Many things, like other medicines and diet changes, can affect your INR. Tell your doctor about any bleeding and follow their instructions to prevent bleeding.
Tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. It is not known if nicardipine will harm your unborn baby. Talk to your doctor about the risks and benefits of taking nicardipine during pregnancy or while breastfeeding.
Warfarin can harm your unborn baby, especially during the first three months of pregnancy. Do not take warfarin if you are pregnant, unless you have a mechanical heart valve and your doctor says the benefits outweigh the risks. Talk to your doctor if you are breastfeeding, and watch your baby for bruising or bleeding.
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How to Read This nicardipine vs warfarin Comparison
nicardipine is classified in the Calcium Channel Blocker drug class, while warfarin sits within the Vitamin K Antagonist (Anticoagulant) class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, nicardipine has 972 submissions while warfarin has 37,036. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to warfarin does not interfere with the way nicardipine attaches to blood proteins.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for nicardipine or warfarin.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.