itraconazole vs lemborexant
PlainMeds reviewed this comparison against our methodology in August 2026. It places FDA and CMS record fields side by side, without recommending either medication.
Side-by-side comparison of itraconazole and lemborexant. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
Examples: Strong CYP3A inhibitors: itraconazole, clarithromycin Moderate CYP3A inhibitors: fluconazole, verapamil Weak CYP3A inhibitors: chlorzoxazone, ranitidine Strong and Moderate CYP3A Inducers Clinical Impact: Concomitant use with a strong or moderate CYP3A inducer decreases lemborexant exposure, which may reduce DAYVIGO efficacy [see Clinical Pharmacology ( 12.3 )].
Sporanox
Dayvigo
Itraconazole capsules are an antifungal medicine. They treat fungal infections in your body.
Dayvigo is a medicine that can help you fall asleep and stay asleep. It is for adults who have trouble with insomnia.
Itraconazole treats fungal infections like blastomycosis, histoplasmosis, and aspergillosis. It can help both people with healthy immune systems and those with weakened immune systems. It also treats onychomycosis, a fungal infection of the toenails or fingernails.
Dayvigo is used to treat insomnia in adults. Insomnia means you have trouble falling asleep, staying asleep, or both. This medicine can help you sleep better.
Itraconazole stops fungi from growing. It does this by interfering with the production of a substance fungi need to build their cell membranes. This eventually kills the fungus and clears the infection.
Dayvigo works by blocking orexin, a chemical in your brain that keeps you awake. By blocking orexin, Dayvigo helps you feel sleepy. This allows you to fall asleep and stay asleep.
- • Nausea
- • Rash
- • Headache
- • Feeling sleepy
- Drug Interaction 1,118
- Pyrexia 568
- Dyspnoea 474
- Pneumonia 461
- Nausea 445
- Suicide Attempt 133
- Somnolence 128
- Condition Aggravated 117
- Suicidal Ideation 115
- Fall 94
Itraconazole can cause congestive heart failure. You should not take this medicine if you have heart problems. Itraconazole can also interact with many other medicines. Some of these interactions can be dangerous or even fatal. Check with your doctor about all the medicines you take.
Dayvigo can make you feel very sleepy, even the next day. Be careful driving or doing other things that need you to be alert. Some people have sleep paralysis, hallucinations, or do things like sleepwalking while taking Dayvigo. Dayvigo may also worsen depression or suicidal thoughts. Do not drink alcohol while taking Dayvigo.
You should not take itraconazole if you are pregnant or plan to become pregnant. It can harm your unborn baby. Talk to your doctor about safe alternatives.
It is not known if Dayvigo can harm your unborn baby. If you are pregnant or plan to become pregnant, talk to your doctor. There is a pregnancy registry for women who take psychiatric medicines, including Dayvigo.
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How to Read This itraconazole vs lemborexant Comparison
itraconazole is classified in the Azole Antifungal drug class, while lemborexant sits within the Orexin Receptor Antagonist class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, itraconazole has 3,066 submissions while lemborexant has 587. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to itraconazole stops the body from breaking down lemborexant normally. this leads to higher levels of the sleep medicine in your blood, which could increase daytime sleepiness.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for itraconazole or lemborexant.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.